Results 21 to 30 of about 285,556 (216)

Appearance of the bladder on initial voiding cystogram in boys with PUV and its relation to pre and postnatal findings

Frontiers in Pediatrics
IntroductionBladder profile in boys with Posterior Urethral Valves can be very varied with a spectrum going from high pressure, unstable, hypocompliant small bladders to hypercompliant, large acontractile bladders, with some being near-normal.
S. Pecorelli, C. Ferdynus, C. Ferdynus, C. Ferdynus, J. Delmas, L. Harper   +5 more
doaj   +1 more source

Bilateral single system ectopic ureters with bilateral urethral insertion and horseshoes kidneys in a female child

Urology Case Reports, 2023
A 14-months old female child was diagnosed with bilateral single system ectopic ureters opening into the urethra, with small bladder capacity, horseshoes kidneys, and bilateral hydronephrosis, presenting recurrent febrile UTI accompanied by continuous ...
Harun Wijanarko Kusuma Putra, Gerhard Reinaldi Situmorang, Arry Rodjani, Irfan Wahyudi   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Balancing Radicality and Function: Prospective Long-Term Outcomes of Muallem Nerve-Sparing Radical Hysterectomy Guided by an Anatomy-Oriented Classification

Diagnostics
Background/Objectives: Radical hysterectomy remains the standard treatment for early-stage cervical cancer. Building on a precise understanding of pelvic anatomy, we previously described a novel nerve-sparing radical hysterectomy technique and ...
Andrea Miranda, Ahmad Sayasneh, Juri Amonti, Jalid Sehouli, Mustafa Zelal Muallem   +4 more
doaj   +1 more source

Forward-Looking Ultrasound Wearable Scanner System for Estimation of Urinary Bladder Volume

Sensors, 2021
Accurate measurement of bladder volume is an important tool for evaluating bladder function. In this study, we propose a wearable bladder scanner system that can continuously measure bladder volume in daily life for urinary patients who need urodynamic ...
Hyeong Geun Jo, Beom Hoon Park, Do Yeong Joung, Jung Ki Jo, Jeong-Kyu Hoh, Won Young Choi, Kwan Kyu Park   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Initiation of bladder voiding with epidural stimulation in paralyzed, step trained rats. [PDF]

PLoS ONE, 2014
The inability to control timely bladder emptying is one of the most serious challenges among the several functional deficits that occur after a complete spinal cord injury. Having demonstrated that electrodes placed epidurally on the dorsum of the spinal
Parag N Gad, Roland R Roy, Hui Zhong, Daniel C Lu, Yury P Gerasimenko, V Reggie Edgerton   +5 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

Neural Regeneration Research
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties. A the Food and Drug Administration-approved Phase I clinical trial has
Wenrui Qu, Xiangbing Wu, Wei Wu, Ying Wang, Yan Sun, Lingxiao Deng, Melissa Walker, Chen Chen, Heqiao Dai, Qi Han, Ying Ding, Yongzhi Xia, George Smith, Rui Li, Nai-Kui Liu, Xiao-Ming Xu   +15 more
doaj   +1 more source