Results 131 to 140 of about 1,939,534 (289)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Developmental stuttering with common and complex phenotypes

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the phenotypic spectrum associated with stuttering. Method Individuals with current or resolved developmental stuttering self‐referred. Surveys assessed stuttering characteristics (onset, negative impact, family history) and health (early development, other conditions). Speech and non‐verbal intelligence were assessed using conversation
Sarah E. Horton, Daisy A. Shepherd, Stephanie Siemers, Miya St John, Juliette Catherall, Ingrid E. Scheffer, Angela T. Morgan   +6 more
wiley   +1 more source

From bladder to systemic syndrome: concept and treatment evolution of interstitial cystitis

, 2015
Sara Dinis,1,2 Joana Tavares de Oliveira,3,4 Rui Pinto,1,5 Francisco Cruz,1,5 CA Tony Buffington,6 Paulo Dinis1,5 1Faculty of Medicine, University of Porto, 2Department of Obstetrics and Gynecology, Hospital de São João, Porto ...
Pinto R, Dinis S, de Oliveira JT, Dinis P, Cruz F, Buffington CAT   +5 more
core  

Academic Achievement Test for Anatomy of the Neck: Validity and Reliability Analysis

European Journal of Dental Education, EarlyView.
ABSTRACT Objective Anatomy education remains a fundamental component of medical and dental curricula, and mastering neck anatomy is particularly challenging due to its structural complexity and clinical relevance. Despite its importance, there is a limited number of validated instruments specifically designed to assess academic achievement in neck ...
Dilber Polat, Halil Yilmaz
wiley   +1 more source

Equine vegetative endocarditis and vertebral osteomyelitis due to refractory Erysipelothrix rhusiopathiae infection

Equine Veterinary Education, EarlyView.
Summary Erysipelothrix rhusiopathiae was the causative agent of vegetative endocarditis and vertebral osteomyelitis in a 24‐year‐old Irish draught gelding that presented with prolonged history of intermittent pyrexia and tachycardia. Clinical investigations revealed persistently reduced neck mobility, tachydysrhythmia and episodic pyrexia up to 41°C ...
E. Kolovou, Z. Daobry, Â. J. F. Mendes, G. Weller, S. Radhakrishnan, M. S. I. Sajib, M. Fuentes, F. Zendri, T. Forde, W. Weir, J. Del‐Pozo, D. G. M. Sutton   +11 more
wiley   +1 more source

Human psychophysiological responses to visceral and somatic pain – the development of integrated, reproducible human pain phenotypes [PDF]

, 2011
PhDBackground Pain is the ubiquitous human experience, yet displays considerable inter- and intraindividual variability in health and disease. Many factors have been proposed to account for these differences.
Farmer, Adam Donald
core  

Menopause and comorbidity assessment in cisgender women living with HIV in Victoria: A clinic record review of women seen at three tertiary centres in Melbourne, Australia

HIV Medicine, EarlyView.
Abstract Background Data on women ageing with HIV in Australia are limited, particularly regarding those in midlife and experiencing menopause. The aim of this study is to describe the demographic characteristics of cisgender women living with HIV who attend the Alfred Hospital, Monash Medical Centre and Melbourne Sexual Health Centre for primary HIV ...
Anna B. Pierce, Sushena Krishnaswamy, Philip Rawson‐Harris, Wajeeha Fatima, Melanie Bissessor, Jennifer F. Hoy   +5 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Updated S2k hidradenitis suppurativa (HS) guidelines provide expert consensus on diagnosis, assessment and comorbidities. Expanded substantially since the 2015 version, they reflect rapid growth in HS literature and aim to improve generalist‐level patient care through evidence‐informed, consensus‐based guidance.
G. B. E. Jemec, B. Villumsen, K. R. van Straalen, H. H. van der Zee, S. Valiukevičienė, T. Tzellos, J. C. Szepietowski, A. Szegedi, D. M. L. Saunte, M. Romanelli, H. Raynal, F. Prignano, E. P. Prens, M. Podda, A. Nassif, A. Molina‐Leyva, Ł. Matusiak, A. V. Marzano, B. M. McGrath, A. I. Liakou, B. Kirby, L. Kemény, E. Just, D. Ioannidis, J. R. Ingram, R. E. Hunger, B. Horváth, P. Guillem, Ø. Grimstad, E. J. Giamarellos‐Bourboulis, M. Dolenc‐Voljč, V. Del Marmol, Z. Bukvić Mokos, V. Bettoli, F. Benhadou, F. G. Bechara, C. C. Zouboulis   +36 more
wiley   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source