Results 121 to 130 of about 65,591 (261)

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, EarlyView.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Contaminants in municipal drinking water, specifically total trihalomethanes (TTHMs), are mutagenic. Exposures to TTHMs have been associated with urothelial carcinoma (UC) in both people and dogs. Mutations in the BRAF gene and other genomic copy number aberrations detected in voided urothelial cells with commercial CADET BRAF and BRAF‐PLUS ...
Janice O'Brien, Samantha L. Braman, Jennifer Willcox, Phillip Wang, Daniel Gerrity, Audrey Ruple, Lauren A. Trepanier   +6 more
wiley   +1 more source

SUBDUE‐3: SUB‐urothelial DUrvalumab‐89zirconium injEction; a phase 0 biodistribution study protocol

BJU International, EarlyView.
Kevin G. Keane, Richard Gauci, Roslyn J. Francis, Andrew M. Scott, Cynthia Hawks, Andrisha‐Jade Inderjeeth, Ian D. Davis, Jayne Lim, Andrew Redfern, Dickon Hayne   +9 more
wiley   +1 more source

Dermatological Adverse Events Associated With Lapatinib Treatment in Dogs With Urothelial Carcinoma: A Retrospective Study

Veterinary Dermatology, EarlyView.
Lapatinib is widely used in human oncology; however, dermatological adverse events (DAEs) are common and have been correlated with treatment efficacy. In veterinary medicine, lapatinib use in combination with piroxicam has been shown to be effective in treating canine urothelial carcinoma (UC); however, the incidence and prognostic significance of DAEs
Kosuke Horita, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda   +3 more
wiley   +1 more source

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

Deep early tumour shrinkage in metastatic upper tract urothelial carcinoma treated with enfortumab vedotin plus pembrolizumab

BJU International, EarlyView.
Marie Semmler, Maurice Heimer, Can Aydogdu, Benazir Enzinger, Isabel Brinkmann, Frederik Kolligs, Gerald B. Schulz, Christian G. Stief, Philipp M. Kazmierczak, Jozefina Casuscelli, Lennert Eismann   +10 more
wiley   +1 more source

Laparoscopic stapled partial cystectomy with intraoperative cystourethroscopy for urothelial carcinoma in two dogs

Veterinary Surgery, EarlyView.
Abstract Objective To describe the procedure and short‐term outcomes of two dogs that underwent laparoscopic stapled partial cystectomy with intraoperative cystoscopy for excision of solitary, non‐trigonal, urothelial carcinoma lesions. Animals A 12‐year‐old female spayed mixed breed and a 13‐year‐old female spayed Siberian Husky.
Maureen A. Griffin, Christian Folk, Nicole J. Buote   +2 more
wiley   +1 more source

Case Report: A Rare Case with Cutaneous Metastasis of Bladder Urothelial Carcinoma

Journal of Medical Sciences
Bladder cancer is a common genitourinary malignancy with variable metastatic potential. Cutaneous metastasis is uncommon and often presents with a poor prognosis.
Min-Jui Wu, Hui-Kung Ting, Ting-Ying Lee, Yu-Cing Juho   +3 more
doaj   +1 more source

Clinical outcomes of BCG‐treated patients with high‐risk non‐muscle‐invasive bladder cancer according to pre‐ and post‐2021 European Association of Urology risk classifications

BJU International, EarlyView.
Tian Ye, Benjamin Tura, Ben Abbotts, Maurice P. Zeegers, K. K. Cheng, Nicholas D. James, Richard T. Bryan   +6 more
wiley   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source