Results 181 to 190 of about 64,876 (258)

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao   +8 more
wiley   +1 more source

Clinical Benefit of PD‐1/PD‐L1 Inhibitors as Standard First‐Line Treatment in Low PD‐L1‐Expressing Advanced Solid Tumors: A Systematic Review and Meta‐Analysis

open access: yesMedComm, Volume 7, Issue 2, February 2026.
This is the first meta‐analysis to focus on the actual clinical benefit of ICIs as standard first‐line therapy for multiple cancers with low PD‐L1 expression, in accordance with current FDA guidelines. The mirror‐based study design enhances precision and accuracy, while ensuring alignment with clinical practice.
Peng Wu   +14 more
wiley   +1 more source

Exploring Pembrolizumab‐Induced IM3OS in a Patient With Bladder Cancer

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Pembrolizumab, an immune checkpoint inhibitor (ICI), has transformed cancer treatment across various malignancies, including metastatic urothelial cancer. As the use of pembrolizumab becomes increasingly widespread, understanding its potential adverse effects is essential.
Ching‐Cheng Chan   +3 more
wiley   +1 more source

Long‐term outcomes of a cascading salvage strategy for high‐risk non‐muscle‐invasive bladder cancer

open access: yesBJU International, Volume 137, Issue 2, Page 339-347, February 2026.
Objective To report long‐term oncological outcomes of patients with high‐risk non‐muscle‐invasive bladder cancer (HR‐NMIBC) undergoing bladder‐sparing therapy (BST) after bacillus Calmette–Guérin (BCG) failure. Patients and Methods We retrospectively reviewed patients with HR‐NMIBC treated from 2000 to 2025 with intravesical therapies after BCG failure,
Ian M. McElree   +5 more
wiley   +1 more source

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