Results 181 to 190 of about 70,987 (344)

Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water

Veterinary and Comparative Oncology, Volume 24, Issue 2, Page 363-369, June 2026.
ABSTRACT Contaminants in municipal drinking water, specifically total trihalomethanes (TTHMs), are mutagenic. Exposures to TTHMs have been associated with urothelial carcinoma (UC) in both people and dogs. Mutations in the BRAF gene and other genomic copy number aberrations detected in voided urothelial cells with commercial CADET BRAF and BRAF‐PLUS ...
Janice O'Brien, Samantha L. Braman, Jennifer Willcox, Phillip Wang, Daniel Gerrity, Audrey Ruple, Lauren A. Trepanier   +6 more
wiley   +1 more source

Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men [PDF]

, 2022
Stanley Teleka, Marju Orho‐Melander, Fredrik Liedberg, Olle Melander, Karin Jirström, Tanja Stocks   +5 more
openalex   +1 more source

Intravesical Delivery of P21 mRNA–Loaded Lipid Nanoparticles as a Tumor Suppressor Replacement Therapy for Bladder Cancer

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intravesical delivery of p21 mRNA‐loaded lipid nanoparticles (p21‐LNP) restores the tumor suppressor p21 in bladder cancer. Localized p21 expression directly induces cell cycle arrest, DNA damage and apoptosis, and ultimately inhibits orthotopic tumor growth with minimal systemic distribution and favorable safety.
Jie Zeng, Ziyi Cao, Chenghe Wang, Yingjie Xu   +3 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, Volume 20, Issue 5, Page 1299-1322, May 2026.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Role of Natural Compounds in Bladder Urothelial Carcinoma Treatment. [PDF]

Int J Mol Sci
Jiang H, Chen Y, Zeng X, Yang R, Zhang F, Zhang H, Zhang E, Wu X, Yan D, Yu C.   +9 more
europepmc   +1 more source

Real-World Clinical Outcomes with First-Line Systemic Treatment and Avelumab Maintenance in US Patients with Locally Advanced or Metastatic Urothelial Carcinoma: The SPEAR Bladder-II Study [PDF]

Sneha Sura, Manojkumar Bupathi, Valerie Morris, Paul Conkling, Karen Todoroff, Abhijeet Bhanegaonkar, Chiemeka Ike   +6 more
openalex   +1 more source

MP44-05 OVEREXPRESSION OF IMMUNE CO-STIMULATORY MOLECULE B7-H4 IS ASSOCIATED WITH POOR SURVIVAL IN BLADDER UROTHELIAL CARCINOMA [PDF]

, 2017
Alexander P. Glaser, Joseph R. Podojil, Stephen G. Miller, Joshua J. Meeks   +3 more
openalex   +1 more source

Molecular subtype concordance and metastatic patterns in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract Molecular subtypes are potential prognostic and predictive tools in muscle‐invasive bladder cancer (MIBC). However, subtype concordance between primary tumors and metastases, as well as subtype‐specific differences in metastatic patterns, remain poorly characterized.
Csilla Olah, Dániel Juhász, Melinda Váradi, Henning Reis, Mulham Al‐Nader, Osama Mahmoud, Barbara T. Grünwald, Viktor Grünwald, Boris Hadaschik, Péter Nyirády, Tibor Szarvas   +10 more
wiley   +1 more source

AKAP7 is a prognostic biomarker involved in immune infiltration of bladder urothelial carcinoma and correlated with ferroptosis. [PDF]

Discov Oncol
Liu H, Mao Q, Wang X, Tang G, Ding G, Wang T, Liu C, Ma X, Cui Y, Wu J.   +9 more
europepmc   +1 more source