Results 71 to 80 of about 65,591 (261)

Plasmacytoid urothelial carcinoma of the bladder

Indian Journal of Pathology and Microbiology, 2014
Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is an uncommon and aggressive variant of urothelial carcinoma associated with late presentation and poor prognosis. Immunohistochemical examination showing expression of epithelial markers, CD138, and losing the membranous expression of E-cadherin confirms evidence of PUC. Here, we report a
Meihua Qin, Gangping Wang, Yanqing Sun, Qun He   +3 more
openaire   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer. [PDF]

PLoS ONE, 2011
DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in bladder urothelial carcinoma has never been reported.The DNA methylation was profiled by ...
Jialou Zhu, Zhimao Jiang, Fei Gao, Xueda Hu, Liang Zhou, Jiahao Chen, Huijuan Luo, Jihua Sun, Song Wu, Yonghua Han, Guangliang Yin, Maoshan Chen, Zujing Han, Xianxin Li, Yi Huang, Weixing Zhang, Fangjian Zhou, Tong Chen, Pingping Fa, Yong Wang, Liang Sun, Huimin Leng, Fenghao Sun, Yuchen Liu, Mingzhi Ye, Huanming Yang, Zhiming Cai, Yaoting Gui, Xiuqing Zhang   +28 more
doaj   +1 more source

Role of angiogenesis in urothelial bladder carcinoma [PDF]

Central European Journal of Urology, 2016
Bladder cancer is the most common urinary tract malignancy in western countries. In recent years, extensive research has suggested that angiogenesis plays an important role in bladder cancer biology, contributing to tumor growth and progression.In this review, we discuss general mechanisms of angiogenesis and highlight the influence of pro- and anti ...
Fus, Łukasz Piotr, Górnicka, Barbara
openaire   +2 more sources

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

A rare case of synchronous association of chromophobe renal cell carcinoma with urothelial carcinoma of urinary bladder

African Journal of Urology, 2017
Introduction: Chromophobe renal cell carcinoma accounts for 3–5% of all RCCs. However, its association with urothelial carcinoma of urinary bladder has never been reported.
A. Chaurasia, S. Padmanabhana, P. Das, J. Aravind   +3 more
doaj   +1 more source

Vaginal cuff recurrence after radical cystectomy: an under - studied site of bladder cancer relapse [PDF]

, 2017
Vaginal cuff recurrence of tumor following radical cystectomy is a rare site of disease recurrence, however it has never been specifically studied. The aim of the study is to evaluate incidence, risk factors, and long-term oncologic outcomes of vaginal ...
Boorjian, Stephen A, Frank, Igor, Karnes, R Jeffrey, Morlacco, Alessandro, Nehra, Avinash, Thapa, Prabin, Zattoni, Fabio   +6 more
core   +1 more source

Urothelial Carcinoma of the Bladder: Radiologic Perspective

Journal of the Korean Society of Radiology, 2021
Bladder cancer is a relatively common cancer type, with a high recurrence rate, that can be often encountered in the imaging study. Accurate diagnosis and staging have a significant impact on determining treatment and evaluating prognosis. Bladder cancer has been evaluated by transurethral resection of bladder tumor for clinical staging and treatment ...
Dong Won Kim, Seong Kuk Yoon, Sang Hyeon Kim   +2 more
openaire   +2 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

FomA‐Containing Outer Membrane Vesicles of Fusobacterium Nucleatum Facilitate Bladder Cancer Lymphatic Metastasis via IL‐6‐Dependent M2b Macrophage Polarization

Advanced Science, EarlyView.
Urinary Fusobacterium nucleatum–derived outer membrane vesicles are shown to promote bladder cancer lymphatic metastasis. The vesicle protein FomA activates TLR2/NF‐κB signaling in tumor cells, induces IL‐6 secretion, and drives M2b macrophage polarization and VEGF‐C–dependent lymphangiogenesis, revealing a microbiota‐driven mechanism linking tumor ...
Wentai Shangguan, Weijia Li, Wenxue Huang, Jilin Wu, Yao Yu, Yiyao Huang, Lin Yang, Ming Xie, Qishen Yang, Jun Zheng, Yuexuan Zhu, Qi Sun, Biao Li, Leqian Li, Zongwei Wang, Jie Zhao, Peng Wu, Bisheng Cheng   +17 more
wiley   +1 more source