Results 191 to 200 of about 200,079 (309)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Film and Diffusion Kinetics of Ammonium Removal from Leachate in an Up-Flow Anaerobic Sludge Blanket Reactor. [PDF]

ACS Omega
Fulazzaky MA, Hariati F, Susetyo B, Yuniarto A, Afrianto Y, Sofyan A, Yuzir A, Zulaika A, Muda K.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes. [PDF]

J Thorac Dis
Zhang X, Lu X, Li F, Gu H, Cheng X, Tang J, Zhang X, Jiang J, Feng L, Li X.   +9 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Development and Validation of a Low-Cost Arduino-Based Lee Disc System for Thermal Conductivity Analysis of Sustainable Roofing Materials. [PDF]

Sensors (Basel)
Negreiros WJAG, Rodrigues JDS, Ribeiro MM, Silva DS, Junio RFP, Seruffo MCDR, Monteiro SN, Corrêa AC.   +7 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Southward impact excavated magma ocean at the lunar South Pole-Aitken basin. [PDF]

Nature
Andrews-Hanna JC, Bottke WF, Broquet A, Evans AJ, Gowman G, Johnson BC, Keane JT, Levin JN, Mallik A, Marchi S, Moruzzi SA, Roy A, Wakita S.   +12 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

But how green is it actually? Calculating the environmental footprint of kidney care environmental optimizations within haemodialysis. [PDF]

Clin Kidney J
Duane B, Larkin J, Caiazzo M, Arenas M, Griffin A, Audije-Gil J, Mortimer F, Attwell H, Yasar A, Martínez-Cadenas R, Arias-Guillén M, Gomez M, Fehintola A, Steinbach I, Ortiz A.   +14 more
europepmc   +1 more source