Results 41 to 50 of about 22,912 (217)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Nuclear Engineering and TechnologyThe International Fusion Materials Irradiation Facility – Demo Oriented Neutron Source (IFMIF-DONES) plays an essential role in testing and qualifying materials for the development of nuclear fusion technology.
F. Mota +4 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Fusion technologies for Laser Inertial Fusion Energy (LIFE)∗
EPJ Web of Conferences, 2013 The Laser Inertial Fusion-based Energy (LIFE) engine design builds upon on going progress at the National Ignition Facility (NIF) and offers a near-term pathway to commercial fusion.
Kramer K.J. +12 more
doaj +1 more source
Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2021 Objective This study aimed to describe and evaluate the dispersion of body-mattress contact pressure on a cardboard bed and investigate whether the cardboard bed has a positive effect on evacuees’ musculoskeletal burden.
Seiji Hamanishi PhD
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Long-term corrosion behavior of ODS-Eurofer in flowing Pb-15.7Li at 550°C
Nuclear Materials and Energy, 2016 Low activation ferritic-martensitic steels (RAFM-steels) are foreseen as structural materials in different blanket designs (HCLL, DCLL, WCLL) with Pb-15.7Li as breeding and partly also as cooling medium.
W. Krauss, S.-E. Wulf, J. Konys
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Nuclear Materials and Energy, 2020 Solid tritium breeding materials are used in a high temperature condition for a long time in a fusion reactor blanket. It is expected that a certain amount of Li will be evaporated and the pebble structure will be changed.
Akito Ipponsugi +2 more
doaj +1 more source