Results 41 to 50 of about 5,132,362 (234)
Cunningham: a BLAST Runtime Estimator [PDF]
, 2011 BLAST is arguably the single most important piece of software ever written for the biological sciences. It is the core of most bioinformatics workflows, being a critical component of genome homology searches and annotation.
Malcolm Matalka +5 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Evaluation of Blast Resistance in Zinc-Biofortified Rice
PlantsRice is a staple food for over half of the world’s population, and it is grown in over 100 countries. Rice blast disease can cause 10% to 30% crop loss, enough to feed 60 million people.
Anita Nunu +8 more
doaj +1 more source
The interaction and pharmacological modulation of the cardiorespiratory responses to primary thoracic blast injury, haemorrhage resuscitation [PDF]
, 2002 Blast injuries represent a problem for civilian and military populations. The response to thoracic blast injury involves a reflex bradycardia, hypotension and apnoea.
Sawdon, Mariana Annette +2 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CABI Agriculture and Bioscience, 2021 Background Finger millet blast disease, caused by Pyricularia oryzae, is a serious constrain of finger millet production which is threatening global food security especially to the resource poor smallholder farmers in arid and semi-arid regions.
Wilton Mbinda +6 more
doaj +1 more source
Journal of Integrative Agriculture, 2021 Blast disease caused by the fungus Magnaporthe grisea results in significant yield losses of cereal crops across the world. To date, very few regulatory genes contributing to blast resistance in grass species have been identified and the genetic basis of
Zhi-jiang LI +10 more
doaj +1 more source
Modelling of the low-impulse blast behaviour of fibre–metal laminates based on different aluminium alloys [PDF]
, 2013 A parametric study has been undertaken in order to investigate the influence of the properties of the aluminium alloy on the blast response of fibre–metal laminates (FMLs).
Guan, Zhongwei +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source