Results 111 to 120 of about 15,213 (294)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Civilian Firearm and blast injuries of the Hand in Lagos, Nigeria

, 2014
A 6 year review of 43 patients who sustained Civilian firearm and blast injuries of the hand at the Lagos University Teaching Hospital was done. Majority of patients seen were young males (93.1%).
Enweluzo, GO, Ugburo, AO, Mofikoya, BO, Akinsulire, AT   +3 more
core   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Pulmonary Primary Blast Injuries

, 2016
Primary underwater explosions are particularly dangerous because of the water properties relative to air, and the resulting pathologies presents difficulty in determining their etiologies.
Uddin, Moe
core  

Blast Injuries by an Improvised Explosive Device in Japan: A Case Report. [PDF]

Cureus, 2022
Kujirai D, Fujii R, Kaito D, Nakama R, Izawa Y.   +4 more
europepmc   +1 more source

Estimating blast exposures from the 2020 Beirut explosion and examining correlation with blast injuries

, 2023
On 4th August 2020, approximately 2750 tonnes of Ammonium Nitrate stored in the port of Beirut ignited, causing a huge explosion that damaged large parts of the city, causing more than 200 deaths and over 7,000 injuries. Injured victims’ locations at the
Denny, Jack, Batchelor, James, Al-Hajj, Samar   +2 more
core  

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Mechanisms of Blast Induced Brain Injuries, Experimental Studies in Rats.

, 2011
Traumatic brain injuries (TBI) potentially induced by blast waves from detonations result in significant diagnostic problems. It may be assumed that several mechanisms contribute to the injury.
Angeria, Maria, Risling, M,, Kirkegaard, M,, Davidsson, Johan,, Arborelius, Ulf, Risling, Mårten, Davidsson, J,, Angeria, Maria,, Angeria, M,, Arbsorelius, U,, Plantman, S,, Bellander, B-M,, Davidsson, Johan, Arborelius, Ulf,, Plantman, Stefan, Rostami, Elham,, Risling, M\ue5rten, Kirkegaard, M, Bellander, Bo Mikael,, Bellander, Bo Mikael, Risling, Mårten,, Plantman, Stefan,, Rostami, Elham   +22 more
core   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source