Results 1 to 10 of about 493,555 (265)

Caveolin-1 scaffolding domain peptide abrogates autophagy dysregulation in pulmonary fibrosis

Scientific Reports, 2022
Idiopathic pulmonary fibrosis (IPF) is the most common and fatal form of interstitial lung disease. IPF is characterized by irreversible scarring of the lungs leading to lung function decline. Although the etiology remains poorly understood, dysregulated
Shalini Venkatesan, Liang Fan, Hua Tang, Nagarjun V. Konduru, Sreerama Shetty   +4 more
doaj   +1 more source

Biomarker-Based Classification of Patients With Acute Respiratory Failure Into Inflammatory Subphenotypes: A Single-Center Exploratory Study

Critical Care Explorations, 2021
OBJECTIVES:. Hyper- and hypoinflammatory subphenotypes discovered in patients with acute respiratory distress syndrome predict clinical outcomes and therapeutic responses. These subphenotypes may be important in broader critically ill patient populations
Callie M. Drohan, MD, S. Mehdi Nouraie, MD, PhD, William Bain, MD, Faraaz A. Shah, MD, MPH, John Evankovich, MD, Yingze Zhang, PhD, Alison Morris, MD, MS, Bryan J. McVerry, MD, Georgios D. Kitsios, MD, PhD   +8 more
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Caveolin-1 peptide regulates p53-microRNA-34a feedback in fibrotic lung fibroblasts

iScience, 2022
Summary: Idiopathic pulmonary fibrosis (IPF) is a life-threatening disease resulting from dysregulated repair responses to lung injury. Excessive extracellular matrix deposition by expanding myofibroblasts and fibrotic lung fibroblasts (fLfs) has been ...
Taryn B. Hogan, Nivedita Tiwari, M.R. Nagaraja, Shwetha K. Shetty, Liang Fan, Rashmi S. Shetty, Yashodhar P. Bhandary, Sreerama Shetty   +7 more
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Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

mBio, 2021
Pseudomonas ...
Hernán F. Peñaloza, Tolani F. Olonisakin, William G. Bain, Yanyan Qu, Rick van der Geest, Jill Zupetic, Mei Hulver, Zeyu Xiong, Michael W. Newstead, Chunbin Zou, Jonathan K. Alder, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee   +13 more
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PAI-1 regulates AT2-mediated re-alveolarization and ion permeability

Stem Cell Research & Therapy, 2023
Background Acute lung injury is characterized by overwhelmingly elevated PAI-1 in both lung edema fluid and the circulating system. The role of increased PAI-1, encoded by Serpine1 gene, in the regeneration of injured lung epithelium has not been ...
Gibran Ali, Mo Zhang, Jianjun Chang, Runzhen Zhao, Yang Jin, Jiwang Zhang, Hong-Long Ji   +6 more
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FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells

Respiratory Research, 2018
Background The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration.
Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli, Yutong Zhao   +7 more
doaj   +1 more source

Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice

Cellular & Molecular Biology Letters, 2023
Background Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received increasing attention owing to its close ...
Juan Song, Miao Li, Cuicui Chen, Jian Zhou, Linlin Wang, Yu Yan, Jun She, Lin Tong, Yuanlin Song   +8 more
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Factor H preserves alternative complement function during ARDS, linked to improved survival

ERJ Open Research, 2023
Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie   +11 more
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Caveolin-1-Related Intervention for Fibrotic Lung Diseases

Cells, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease (ILD) for which there are no effective treatments. Lung transplantation is the only viable option for patients with end-stage PF but is only available to a minority ...
Sreerama Shetty, Steven Idell
doaj   +1 more source

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Nature Communications, 2017
How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.
Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. Mallampalli   +9 more
doaj   +1 more source