Results 11 to 20 of about 493,555 (265)

War injuries of the lungs [PDF]

European Journal of Cardio-Thoracic Surgery, 1997
The authors' experience in the treatment of war injuries of the lungs, gained during the war in Croatia, from August 25, 1991 until July 1, 1995, is presented. In that period, 424 patients with injuries of the lungs were treated at the Split Clinical Hospital.The paper is a retrospective study of 424 wounded persons with lung injuries gained during the
A, Petricevic, N, Ilic, A, Bacic, M, Petricevic, V, Vidjak, S, Tanfara   +5 more
openaire   +2 more sources

The topical study of inhaled drug (salbutamol) delivery in idiopathic pulmonary fibrosis

Respiratory Research, 2018
Background Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF). Methods The TOPICAL study was a 4-period, partially-randomised, controlled, crossover study to investigate four ...
Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey, Toby M. Maher   +9 more
doaj   +1 more source

Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury

EBioMedicine, 2016
Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao, Jianxin Wei, Su Dong, Rachel K. Bowser, Lina Zhang, Anastasia M. Jacko, Yutong Zhao   +6 more
doaj   +1 more source

Acute lung injury [PDF]

Clinical Medicine, 2011
#### Key points Acute lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are the pulmonary manifestations of an acute systemic inflammatory process characterised clinically by pulmonary infiltrates, hypoxaemia and oedema.
Dhruv, Parekh, Rachel C, Dancer, David R, Thickett   +2 more
openaire   +2 more sources

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

eLife, 2016
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through ...
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen   +9 more
doaj   +1 more source

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor

Journal of Immunology Research, 2015
Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates tissue recovery from influenza and Staph aureus infection.
Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington   +4 more
doaj   +1 more source

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

Frontiers in Immunology, 2021
The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized.
Hernán F. Peñaloza, Rick van der Geest, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee, Janet S. Lee   +5 more
doaj   +1 more source

Ventilator-Induced Lung Injury [PDF]

New England Journal of Medicine, 2013
To the Editor: Slutsky and Ranieri (Nov. 28 issue)(1) note that ventilator-induced lung injury may be minimized by means of lung-protective mechanical ventilation or by avoiding it altogether with the use of extracorporeal life-support techniques(2) such as by extracorporeal removal of carbon dioxide or extracorporeal membrane oxygenation (ECMO ...
S Mohammadreza, Hashemian, Seyed A, Mohajerani, Hamidreza R, Jamaati   +2 more
openaire   +8 more sources

E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

Cell Reports, 2014
Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by
Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli   +19 more
doaj   +1 more source

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Yohei Doi, Melanie J. Harriff, Melanie J. Harriff, Janet S. Lee, Janet S. Lee, Janet S. Lee   +19 more
doaj   +1 more source