Results 71 to 80 of about 15,213 (294)

Management of extensive maxillofacial injury related to a Tyre Blast: A rare case report

Saudi Dental Journal, 2018
Background: Severe blast injuries of large tyres are similar to those resulting from explosions with neither thermal nor chemical effects. The literature related to the destructive nature of these blasts is very sparse.
Sanjay S. Rao, Sridhar D. Baliga, Abhinav Bhatnagar   +2 more
doaj   +1 more source

Investigating the use of rubber to attenuate the effect of blast load applied to a surrogate lower leg

, 2008
Includes abstract.Includes bibliographical references (leaves 191-197).Landmines are the epitome of the perfect soldier: always ready, never tiring. Landmines also do not choose their victims - it may very well be an armed and protected soldier or an ...
Ungerer, Delmarie
core  

Injuries underbody blast fatalities: identification of five distinct mechanisms of head injury

, 2022
Previous research has shown that injuries to the head and neck were prevalent in 73% of all mounted fatalities of underbody blast. The mechanisms that cause such injuries to the central nervous system are not yet known.
Baxter, D, Gibb, I, Wilson, Mark, Ashworth, Emily, Bull, anthony   +4 more
core   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Blast injuries and brain trauma:An overview [PDF]

, 2014
Bomb explosions frequently cause devastating multiple injuries (polytrauma). Medical students should have an appreciation of the pattern and mechanism of the injuries caused by bomb blast and the early care of the injured.
Miller, Rowan JS, Rosenfeld, Jeffrey V.
core  

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Explosions and blast injuries : a primer for clinicians [PDF]

As the risk of terrorist attacks increases in the U.S., disaster response personnel must understand the unique pathophysiology of injuries associated with explosions and must be prepared to assess and treat the people injured by ...

core  

Prospects for studying how high-intensity compression waves cause damage in human blast injuries

, 2012
Since World War I, explosions have accounted for over 70% of all injuries in conflict. With the development of improved personnel protection of the torso, improved medical care and faster aeromedical evacuation, casualties are surviving with more severe ...
Bonner, Timothy, William Proud, Adam Hill, Spyros Masouros, Timothy Bonner, Bull, Anthony, Nicolas Newell, Ramasamy, Arul, Balzer, Jens, Chiara Bo, Arul Ramasamy, Masouros, Spyros, Newell, Nicolas, Proud, William, Jens Balzer, Jon Clasper, Hill, Adam, Bo, Chiara, Katherine Brown, Clasper, Jon, Anthony Bull, Brown, Katherine   +21 more
core   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source