Results 41 to 50 of about 138,438 (256)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Introgression of blast resistance genes (putative Pi-b and Pi-kh) into elite rice cultivar MR219 through Marker-Assisted Selection

Frontiers in Plant Science, 2015
Blast is the most common biotic stress leading to the reduction of rice yield in many rice-growing areas of the world, including Malaysia. Improvement of blast resistance of rice varieties cultivated in blast endemic areas is one of the most important ...
Fatah A Tanweer, Mohd Yusop Rafii, K eSijam, Harun A Rahim, F eAhmed, Sadegh eAshkani, Sadegh eAshkani, Mohammad Abdul Latif   +7 more
doaj   +1 more source

Improving rice blast resistance by stacking of two broad spectrum resistance gene Pi9 and Pi54 in cultivar CO 51 through Marker Assisted Selection

Electronic Journal of Plant Breeding, 2023
Blast disease is a highly destructive disease and causes significant yield losses in rice. To address this issue, this study was chosen and focused on stacking of the Pi9along with CO 51+Pi54, which provide broad-spectrum resistance to blast pathogen ...
S. Samuthirapandi1, T. Thiyagarajan2, S. Viswabharathy1, A. Bharathi2, K. Rohit2, R. Veera Ranjani2, M. Sudha 2, C. Gopala Krishnan3, T. Kalaimagal4, M. Raveendran5 and S. Manonmani3*
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Two genomic regions of a sodium azide induced rice mutant confer broad-spectrum and durable resistance to blast disease

Rice, 2022
Rice blast, one of the most destructive epidemic diseases, annually causes severe losses in grain yield worldwide. To manage blast disease, breeding resistant varieties is considered a more economic and environment-friendly strategy than chemical control.
Kuan-Lin Lo, Yi-Nian Chen, Min-Yu Chiang, Mei-Chun Chen, Jerome P. Panibe, Chung-Chun Chiu, Lu-Wei Liu, Liang-Jwu Chen, Chun-Wei Chen, Wen-Hsiung Li, Chang-Sheng Wang   +10 more
doaj   +1 more source

Predicting Protein–Protein Interactions Between Rice and Blast Fungus Using Structure-Based Approaches

Frontiers in Plant Science, 2021
Rice blast, caused by the fungus Magnaporthe oryzae, is the most devastating disease affecting rice production. Identification of protein–protein interactions (PPIs) is a critical step toward understanding the molecular mechanisms underlying resistance ...
Cunjian Zheng, Yuan Liu, Fangnan Sun, Lingxia Zhao, Lida Zhang   +4 more
doaj   +1 more source

On the blast resistance of laminated glass

International Journal of Solids and Structures, 2012
AbstractBlast resistant glazing systems typically use laminated glass to reduce the risk of flying glass debris in the event of an explosion. Laminated glass has one or more bonded polymer interlayers to retain glass fragments upon fracture. With good design, the flexibility of the interlayer and the adhesion between layers enable laminated glass to ...
Hooper, PA, Sukhram, RAM, Blackman, BRK, Dear, JP   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Refinement of rice blast disease resistance QTLs and gene networks through meta-QTL analysis

Scientific Reports
Rice blast disease is the most devastating disease constraining crop productivity. Vertical resistance to blast disease is widely studied despite its instability.
Basavantraya Navadagi Devanna, Sumali Sucharita, N. C. Sunitha, C. Anilkumar, Pankaj K. Singh, D. Pramesh, Sanghamitra Samantaray, Lambodar Behera, Jawahar Lal Katara, C. Parameswaran, Prachitara Rout, Selvaraj Sabarinathan, Hosahatti Rajashekara, Tilak Raj Sharma   +13 more
doaj   +1 more source