Results 1 to 10 of about 133,124 (219)
Genome-wide association study (GWAS) of high productivity classes in the Karachaevsky sheep breed [PDF]
Journal of Central European Agriculture, 2021 Using the Illumina Ovine Infinium HD BeadChip 600K DNA array, we performed a genome-wide association study (GWAS) in Karachaevsky breed sheep with different class evaluations (elite and super-elite).
Alexander Krivoruchko +3 more
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Cluster analysis of milk fat yield trait in dairy cows using meta-analysis of the genome-wide association studies [PDF]
پژوهش های علوم دامی, 2022 Introduction: Cow's milk is one of the most important animal products for any country and known as an important source for fat and protein originated from animals (Fenelon and Guinee, 1999, Martini et al., 2016).
S Bakhshalizadeh1, S Zerehdaran2* and A Javadmanesh3
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Y染色体嵌合缺失与心脑血管疾病 Mosaic Loss of Y Chromosome and Cardio-and Cerebrovascular Diseases
Zhongguo cuzhong zazhi, 2023 研究提示，外周血白细胞发生Y染色体嵌合缺失（mosaic loss of chromosome Y，mLOY）增加全因死亡和心脑血管等年龄相关疾病的风险。mLOY是男性特有的遗传变异因素，高龄、吸烟、空气污染等可能是mLOY的危险因素。近年来的全基因组关联分析（genome wide association studies，GWAS）研究发现了不少与mLOY相关的基因位点。基础研究和基于人类基因数据库的分析提示mLOY对心脑血管疾病的发生和复发、预后有不良影响，其可能机制有“免疫监控”假说和“共同土壤 ...
李嫣然, 程丝, 赵曼曼, 李昊, 王拥军
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G3: Genes, Genomes, Genetics, 2020 Linkage and association mapping populations are crucial public resources that facilitate the characterization of trait genetic architecture in natural and agricultural systems.
Marcus T. Brock +3 more
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The contribution of non-coding regulatory elements to cardiovascular disease [PDF]
Open Biology, 2020 Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate
Diego Villar +3 more
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Fine-mapping cis-regulatory variants in diverse human populations
eLife, 2019 Genome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and their molecular mechanisms remain unknown.
Ashley Tehranchi +6 more
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A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency
eLife, 2020 N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears.
Dana M Talsness +11 more
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G3: Genes, Genomes, Genetics, 2020 There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross ...
Xinzhu Zhou +7 more
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تجزیه و تحلیل غنی سازی مجموعه های ژنی با استفاده از مطالعه گسترده پویش ژنوم برای شناسایی ژن ها و مسیرهای زیستی مرتبط با دوقلوزایی در گوسفند بلوچی [PDF]
تحقیقات تولیدات دامی, 2019 گوسفند بلوچی یکی از نژادهای بومی ایران است که از شرق کشور منشا گرفته و با شرایط آب و هوایی آن منطقه سازگار شده است. بازده اقتصادی اصلاح نژاد گوسفند به طور واضحی با بازده تولیدمثل میشها مرتبط است. در این پژوهش، صفت دوقلوزایی به عنوان یک صفت تولیدمثلی مهم
سید مهدی اسماعیلی فرد +3 more
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Genome-wide association study for anther length in some elite bread wheat germplasm
Czech Journal of Genetics and Plant Breeding, 2018 The anther is a crucial organ for the development of the spike in bread wheat (Triticum aestivum L.). Long anthers contain large amounts of pollen grains; thus, they are favourable for cross-pollination and increase resilience against adverse ...
Xiaopeng SONG +4 more
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