Results 31 to 40 of about 191,618 (313)

GWAS quality score for evaluating associated regions in GWAS analyses

Bioinformatics, 2023
Abstract Motivation The number of significantly associated regions reported in genome-wide association studies (GWAS) for polygenic traits typically increases with sample size. A traditional tool for quality control and identification of significant regions has been a visual inspection of how ...
Swapnil Awasthi, Chia-Yen Chen, Max Lam, Hailiang Huang, Stephan Ripke, C. Anthony Altar   +5 more
openaire   +3 more sources

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

Epigenetics, 2020
A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants because only a very small percentage of variants associated with a given trait actually impact the trait. We
Xiao Zhang, Kenneth C. Ehrlich, Fangtang Yu, Xiaojun Hu, Xiang-He Meng, Hong-Wen Deng, Hui Shen, Melanie Ehrlich   +7 more
doaj   +1 more source

Functional analysis and signaling pathway enrichment analysis of genes associated with Alzheimer’s disease and Parkinson’s disease

Бюллетень сибирской медицины, 2020
We identified significant functions of susceptibility-genes and performed an analysis of pathway enrichment for Alzheimer’s disease, Parkinson’s disease and for both of them.
N. Yu. Chasovskikh, A. Yu. Grechishnikova, D. V. Smirnov   +2 more
doaj   +1 more source

Cluster analysis of milk fat yield trait in dairy cows using meta-analysis of the genome-wide association studies [PDF]

پژوهش های علوم دامی, 2022
Introduction: Cow's milk is one of the most important animal products for any country and known as an important source for fat and protein originated from animals (Fenelon and Guinee, 1999, Martini et al., 2016).
S Bakhshalizadeh1, S Zerehdaran2* and A Javadmanesh3
doaj   +1 more source

Features of functional annotation of rheumatoid arthritis susceptibility genes by Cytoscape

Бюллетень сибирской медицины, 2020
Aim. To evaluate the functional annotation of genes associated with rheumatoid arthritis with different parameters of the ClueGO Cytoscape tool.Materials and methods.
N. Yu. Chasovskikh
doaj   +1 more source

GWAS in lung disease [PDF]

Thorax, 2011
We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. 1 While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem ...
Robert P, Young, Raewyn J, Hopkins
openaire   +2 more sources

GWAS

, 2022
These are the synthetic datasets we used in our paper.
Yan Gao (9200405)
core   +1 more source

Maximum difference analysis: a new empirical method for genome-wide association studies

Italian Journal of Animal Science, 2016
The availability of high-density single nucleotide polymorphism (SNPs) panels for humans and, recently, for several livestock species has given a great impulse to genome-wide association studies towards the identification of genes associated with complex
Massimo Cellesi, Corrado Dimauro, Silvia Sorbolini, Ezequiel Luis Nicolazzi, Giustino Gaspa, Paolo Ajmone-Marsan, Nicolò Pietro Paolo Macciotta   +6 more
doaj   +1 more source

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Heinzmann, Andrea, Ruether, Andreas, Otto Laub, Bufe, A., Lathrop, M, Schedel, M., Michel, Sven, Ruether, A., Michel, S., Schreiber, Stefan, von Berg, A., Gut, I.G., Christian Vogelberg, Ernst Rietschel, von Mutius, E., Burkhard Simma, Schreiber, S., Klopp, N., Schedel, Michaela, Depner, Martin, Laub, O., Liang, Liming, Stefan Schreiber, Illig, T., Rietschel, E., Michael Kabesch, Gut, Ivo Glynne, Mutius, Erika von, Frischer, T., Kabesch, Michael, Kabesch, M., Lathrop, Mark, Frischer, Thomas, Ashish Kumar, Jon Genuneit, Gut, Ivo G., Albrecht Bufe, Mark Lathrop, Kumar, A., Rietschel, Ernst, Ivo G. Gut, Illig, Thomas, Martin Depner, Liming Liang, Heinzmann, A., Andrea von Berg, Laub, Otto, Thomas Illig, Andreas Ruether, Simma, B., Vogelberg, Christian, Bufe, Albrecht, Erika von Mutius, Simma, Burkhard, Ivo G Gut, Kumar, Ashish, Sven Michel, Liang, L.M., Depner, M., Berg, Andrea von, Thomas Frischer, Michaela Schedel, Genuneit, J., Genuneit, Jon, Vogelberg, C., Norman Klopp, Klopp, Norman, Andrea Heinzmann   +67 more
core   +2 more sources

Rpv34: the noval Plasmopara viticola resistance locus in 'Moldova'

Fruit Research
Downy mildew (DM), caused by Plasmopara viticola, is one of the most serious diseases that affects grape production worldwide. Utilizing host resistance, commonly known as 'R' genes, is considered the most effective way to cure the disease.
Yan Sun, Bohan Yang, Minmin Li, Changjiang Liu, Yonggang Yin, Nan Jia, Xinyu Wang, Qingming Zeng, Yong Guo, Yingjie Wang, Guohong Wu, Qinqin Gu, Jianfeng Lou, Peining Fu, Bin Han   +14 more
doaj   +1 more source