Results 31 to 40 of about 198,268 (313)

The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update

Genes, 2023
Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among autoimmune diseases, which are polygenic complex traits caused by the combined contribution of genetic and environmental factors, PBC exhibits the strongest involvement of genetic ...
Hitomi, Yuki, Nakamura, Minoru
openaire   +2 more sources

Genetic Networks Underlying Natural Variation in Basal and Induced Activity Levels in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2020
Exercise is recommended by health professionals across the globe as part of a healthy lifestyle to prevent and/or treat the consequences of obesity. While overall, the health benefits of exercise and an active lifestyle are well understood, very little ...
Louis P. Watanabe, Cameron Gordon, Mina Y. Momeni, Nicole C. Riddle   +3 more
doaj   +1 more source

GWAS quality score for evaluating associated regions in GWAS analyses

Bioinformatics, 2023
Abstract Motivation The number of significantly associated regions reported in genome-wide association studies (GWAS) for polygenic traits typically increases with sample size. A traditional tool for quality control and identification of significant regions has been a visual inspection of how ...
Swapnil Awasthi, Chia-Yen Chen, Max Lam, Hailiang Huang, Stephan Ripke, C. Anthony Altar   +5 more
openaire   +3 more sources

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

Epigenetics, 2020
A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants because only a very small percentage of variants associated with a given trait actually impact the trait. We
Xiao Zhang, Kenneth C. Ehrlich, Fangtang Yu, Xiaojun Hu, Xiang-He Meng, Hong-Wen Deng, Hui Shen, Melanie Ehrlich   +7 more
doaj   +1 more source

Functional analysis and signaling pathway enrichment analysis of genes associated with Alzheimer’s disease and Parkinson’s disease

Бюллетень сибирской медицины, 2020
We identified significant functions of susceptibility-genes and performed an analysis of pathway enrichment for Alzheimer’s disease, Parkinson’s disease and for both of them.
N. Yu. Chasovskikh, A. Yu. Grechishnikova, D. V. Smirnov   +2 more
doaj   +1 more source

Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver: A two-sample Mendelian randomization study

The Saudi Journal of Gastroenterology, 2023
Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown.
Qi Sheng, Huanchen Shi, Shousheng Liu, Likun Zhuang, Zhenzhen Zhao, Yongning Xin   +5 more
doaj   +1 more source

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Heinzmann, Andrea, Ruether, Andreas, Otto Laub, Bufe, A., Lathrop, M, Schedel, M., Michel, Sven, Ruether, A., Michel, S., Schreiber, Stefan, von Berg, A., Gut, I.G., Christian Vogelberg, Ernst Rietschel, von Mutius, E., Burkhard Simma, Schreiber, S., Klopp, N., Schedel, Michaela, Depner, Martin, Laub, O., Liang, Liming, Stefan Schreiber, Illig, T., Rietschel, E., Michael Kabesch, Gut, Ivo Glynne, Mutius, Erika von, Frischer, T., Kabesch, Michael, Kabesch, M., Lathrop, Mark, Frischer, Thomas, Ashish Kumar, Jon Genuneit, Gut, Ivo G., Albrecht Bufe, Mark Lathrop, Kumar, A., Rietschel, Ernst, Ivo G. Gut, Illig, Thomas, Martin Depner, Liming Liang, Heinzmann, A., Andrea von Berg, Laub, Otto, Thomas Illig, Andreas Ruether, Simma, B., Vogelberg, Christian, Bufe, Albrecht, Erika von Mutius, Simma, Burkhard, Ivo G Gut, Kumar, Ashish, Sven Michel, Liang, L.M., Depner, M., Berg, Andrea von, Thomas Frischer, Michaela Schedel, Genuneit, J., Genuneit, Jon, Vogelberg, C., Norman Klopp, Klopp, Norman, Andrea Heinzmann, Liang Liming, Schedel Michaela, Schreiber Stefan, Ruether Andreas, Depner Martin, Kabesch Michael, Simma Burkhard, Gut Ivo G., Illig Thomas, von Berg Andrea, Kumar Ashish, Frischer Thomas, Laub Otto, Rietschel Ernst, Heinzmann Andrea, Klopp Norman, Michel Sven, Bufe Albrecht, von Mutius Erika, Genuneit Jon, Lathrop Mark, Vogelberg Christian   +89 more
core   +2 more sources

Features of functional annotation of rheumatoid arthritis susceptibility genes by Cytoscape

Бюллетень сибирской медицины, 2020
Aim. To evaluate the functional annotation of genes associated with rheumatoid arthritis with different parameters of the ClueGO Cytoscape tool.Materials and methods.
N. Yu. Chasovskikh
doaj   +1 more source

GWAS in lung disease [PDF]

Thorax, 2011
We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. 1 While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem ...
Robert P, Young, Raewyn J, Hopkins
openaire   +2 more sources

High marks for GWAS [PDF]

Nature Genetics, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
openaire   +2 more sources