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Analyses of genome-wide association studies (GWAS) show that common SNPs can account for the majority of the heritability of complex traits, but that there are likely to be limits to the usefulness of the current strategy of accumulating common variants of small effect for risk prediction.
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GWAS is going to the dogs [PDF]
AbstractGenome-wide association studies in canine models may help locate genomic susceptibility regions that are relevant to human disease.See related Research: http://genomebiology.com/2014/15/3 ...
Machiela, Mitchell J, Chanock, Stephen J
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hchenBioinfo/Pancancer-GWAS-APA-analysis: CancerAPA v1.1
We released the pipeline to analyze systematically cancer GWAS by integrating with 3'aQTLs across 49 tissues from GTEx ...
Chen wenyan, hchenBioinfo, Xudong Zou
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Deep interpretability for GWAS
Accepted at ICML 2020 workshop on ML Interpretability for Scientific ...
Deepak Sharma +6 more
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Genome wide association studies (GWAS) have revealed a large number of links between genome variation and complex disease. Among other benefits, it is expected that these insights will lead to new therapeutic strategies, particularly the identification of new drug targets.
Cao, Chen, Moult, John
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Achieving GWAS with homomorphic encryption [PDF]
Abstract Background One way of investigating how genes affect human traits would be with a genome-wide association study (GWAS). Genetic markers, known as single-nucleotide polymorphism (SNP), are used in GWAS. This raises privacy and security concerns as these genetic markers can be used to identify individuals uniquely.
Jun Jie Sim +4 more
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On the anniversary of Academician of the Russian Academy of Sciences Olga Silvestrovna Afanasenko
In December 2023, the leading mycologist-phytopathologist of the Russian Federation, head of the laboratory of plant immunity to diseases of the All-Russian Research Institute of Plant Protection (VIZR), Doctor of Biological Sciences, Professor ...
I. G. Loskutov, O. N. Kovaleva
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One of the main pathogens affecting rainbow trout (Oncorhynchus mykiss) farming is the facultative intracellular bacteria Piscirickettsia salmonis. Current treatments, such as antibiotics and vaccines, have not had the expected effectiveness in field ...
Agustin Barria +6 more
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POPULATION STRUCTURE AND GENOME-WIDE ASSOCIATION ANALYSIS FOR SALINITY TOLERANCE IN BREAD WHEAT USING SNP, SSR AND SCOT MARKER ASSAYS [PDF]
Wheat is an essential staple food in the developing world, where demand is projected to grow exponentially in the future; simultaneously, climate changes are projected to reduce supply in the near future. One of the main consequences of climate change is
Alsamman Alsamman +5 more
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Reducing GWAS Complexity [PDF]
Genome-wide association studies (GWAS) have revealed numerous genomic 'hits' associated with complex phenotypes. In most cases these hits, along with surrogate genetic variation as measure by numerous single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium, are not in coding genes making assignment of functionality or causality ...
Dennis J, Hazelett +8 more
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