Results 41 to 50 of about 241,345 (301)
Molecular genetic aspects of sudden cardiac death: a literature review
Бюллетень сибирской медицины, 2018 Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for ...
A. A. Ivanova, V. N. Maksimov
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Y染色体嵌合缺失与心脑血管疾病 Mosaic Loss of Y Chromosome and Cardio-and Cerebrovascular Diseases
Zhongguo cuzhong zazhi, 2023 研究提示，外周血白细胞发生Y染色体嵌合缺失（mosaic loss of chromosome Y，mLOY）增加全因死亡和心脑血管等年龄相关疾病的风险。mLOY是男性特有的遗传变异因素，高龄、吸烟、空气污染等可能是mLOY的危险因素。近年来的全基因组关联分析（genome wide association studies，GWAS）研究发现了不少与mLOY相关的基因位点。基础研究和基于人类基因数据库的分析提示mLOY对心脑血管疾病的发生和复发、预后有不良影响，其可能机制有“免疫监控”假说和“共同土壤 ...
李嫣然, 程丝, 赵曼曼, 李昊, 王拥军
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Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]
, 2019 BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas +5 more
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Thorax, 2011 We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. 1 While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem ...
Robert P, Young, Raewyn J, Hopkins
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Gene and Pathway-Based Analysis: Second Wave of Genome-wide Association Studies [PDF]
, 2008 Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis.
Christopher I. Amos +11 more
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Genetic associations with childhood brain growth, defined in two longitudinal cohorts [PDF]
, 2018 Genome-wide association studies (GWASs) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet,
Jansen, Philip R. +11 more
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Hope for GWAS: Relevant Risk Genes Uncovered from GWAS Statistical Noise [PDF]
International Journal of Molecular Sciences, 2014 Hundreds of genetic variants have been associated to common diseases through genome-wide association studies (GWAS), yet there are limits to current approaches in detecting true small effect risk variants against a background of false positive findings.
Correia, Catarina +4 more
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Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt +5 more
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Tobacco Induced DiseasesIntroduction It is currently uncertain whether smoking is a risk factor for carpal tunnel syndrome (CTS). This study aims to elucidate association between smoking and CTS using Mendelian randomization (MR) analysis.
Wei Shi+ +3 more
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