Results 41 to 50 of about 191,618 (313)

High marks for GWAS [PDF]

open access: yesNature Genetics, 2009
Two genome-wide association studies for testicular cancer report associations at three new loci, including two candidate genes previously implicated in testicular development, KITLG (ligand for the receptor tyrosine kinase) and SPRY4 (sprouty 4).
openaire   +2 more sources

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis [PDF]

open access: yes, 2013
Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These
Vermeire, S   +308 more
core   +3 more sources

Selective sweep and GWAS provide insights into adaptive variation of Populus cathayana leaves

open access: yesForestry Research
Leaf morphology plays a crucial role in predicting the productivity and environmental adaptability of forest trees, making it essential to understand the genetic mechanisms behind leaf variation.
Xinglu Zhou   +4 more
doaj   +1 more source

AdliLab/Fibroid-GWAS-Manuscript: v1.0.0_Fibroid_GWAS_Manuscript_Code

open access: yes, 2023
<p>This repository contains the R code that was used to analyze the manuscript "Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types"</p ...
Mazhar Adli
core   +1 more source

Molecular genetic aspects of sudden cardiac death: a literature review

open access: yesБюллетень сибирской медицины, 2018
Sudden cardiac death (SCD) continues to be a relevant and significant problem in modern medicine. Modern trends in medicine are associated with the widespread introduction of personalized, preventive strategies aimed at correcting risk factors for ...
A. A. Ivanova, V. N. Maksimov
doaj   +1 more source

Y染色体嵌合缺失与心脑血管疾病 Mosaic Loss of Y Chromosome and Cardio-and Cerebrovascular Diseases

open access: yesZhongguo cuzhong zazhi, 2023
研究提示,外周血白细胞发生Y染色体嵌合缺失(mosaic loss of chromosome Y,mLOY)增加全因死亡和心脑血管等年龄相关疾病的风险。mLOY是男性特有的遗传变异因素,高龄、吸烟、空气污染等可能是mLOY的危险因素。近年来的全基因组关联分析(genome wide association studies,GWAS)研究发现了不少与mLOY相关的基因位点。基础研究和基于人类基因数据库的分析提示mLOY对心脑血管疾病的发生和复发、预后有不良影响,其可能机制有“免疫监控”假说和“共同土壤 ...
李嫣然, 程丝, 赵曼曼, 李昊, 王拥军
doaj   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +928 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Give GWAS a Chance [PDF]

open access: yesDiabetes, 2017
From 2007 to 2015, genome-wide association studies (GWAS) resulted in the discovery of over 260 genetic loci associated with obesity and type 2 diabetes (T2D) (1,2). Although GWAS have validated “old culprits” (e.g., PPARG , KCNJ11 ), illuminated novel disease-causing biological pathways (e.g., the zinc transporter SLC30A8 ), and have led to quick ...
openaire   +2 more sources

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