Results 51 to 60 of about 198,268 (313)

Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development

open access: yesActa Pharmaceutica, 2023
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be
Baranasic Jurica   +9 more
doaj   +1 more source

Genome-wide analysis in the search for candidate genes associated with meat productivity traits in meat-and-dairy goats

open access: yesТеория и практика переработки мяса, 2022
The development of the tourism cluster in the North Caucasus causes the expansion of product range with high consumer characteristics, in particular, a sustainable offer of dairy and meat products labeled as environmentally friendly. In the range of such
M. I. Selionova   +4 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai   +13 more
wiley   +1 more source

Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis

open access: yesTobacco Induced Diseases
Introduction It is currently uncertain whether smoking is a risk factor for carpal tunnel syndrome (CTS). This study aims to elucidate association between smoking and CTS using Mendelian randomization (MR) analysis.
Wei Shi+   +3 more
doaj   +1 more source

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

open access: yesNature and Science of Sleep, 2022
Yu-Chin An,1 Chia-Lin Tsai,2 Chih-Sung Liang,3 Yu-Kai Lin,2 Guan-Yu Lin,2 Chia-Kuang Tsai,2 Yi Liu,2 Sy-Jou Chen,1 Shih-Hung Tsai,1 Kuo-Sheng Hung,4 Fu-Chi Yang2 1Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical ...
An YC   +10 more
doaj  

GWAS summary statistic plots.

open access: yes, 2023
(A) GWAS p-value histogram and (B) Manhattan plots for the four GWAS. Genome-wide significance level (−log10(5 × 10−8)) is indicated by the red line.
Dongjun Chung (213776)   +4 more
core   +1 more source

Give GWAS a Chance [PDF]

open access: yesDiabetes, 2017
From 2007 to 2015, genome-wide association studies (GWAS) resulted in the discovery of over 260 genetic loci associated with obesity and type 2 diabetes (T2D) (1,2). Although GWAS have validated “old culprits” (e.g., PPARG , KCNJ11 ), illuminated novel disease-causing biological pathways (e.g., the zinc transporter SLC30A8 ), and have led to quick ...
openaire   +2 more sources

lanec-unifesspa/gwas-pd: Datapackage: Exploratory analysis of GWAS metanalyses of panic disorder

open access: yes, 2017
Data packages for the research project "Exploratory analyses of GWAS data on ...
Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff"
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

open access: yesAdvanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun   +27 more
wiley   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

open access: yes, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs.
Seedorf, Udo   +999 more
core   +1 more source

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