Results 51 to 60 of about 191,618 (313)

A decade in psychiatric GWAS research [PDF]

Molecular Psychiatry, 2018
After more than 10 years of accumulated efforts, genome-wide association studies (GWAS) have led to many findings, most of which have been deposited into the GWAS Catalog. Between GWAS's inception and March 2017, the GWAS Catalog has collected 2429 studies, 1818 phenotypes, and 28,462 associated SNPs.
Tanya Horwitz, Katie Lam, Yu Chen, Yan Xia, Chunyu Liu   +4 more
openaire   +2 more sources

Dutch population structure across space, time and GWAS design [PDF]

, 2020
Previous genetic studies have identified local population structure within the Netherlands; however their resolution is limited by use of unlinked markers and absence of external reference data.
Project MinE ALS GWAS Consortium
core  

Principles for the post-GWAS functional characterisation of risk loci [PDF]

, 2010
Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3.
Chris Carlson, Ian Mills, Christoph Plass, Michael James, Graham Casey, Haris Vikis, Matthew L. Freedman, Jay W. Tichelaar, Simon Gayther, Ming You, Pengyuan Liu, Ian G. Mills, Alvaro N. A. Monteiro, Haris G. Vikis, Gerhard Coetzee, Matthew Freedman, Gerhard A. Coetzee, Dave Duggan, Angela Risch, Mariella De Biasi, Alvaro Monteiro, Jay Tichelaar, Simon A. Gayther   +22 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis

Tobacco Induced Diseases
Introduction It is currently uncertain whether smoking is a risk factor for carpal tunnel syndrome (CTS). This study aims to elucidate association between smoking and CTS using Mendelian randomization (MR) analysis.
Wei Shi^{+, Kaixuan Wu+, Hui Li, Huafeng Zhang   +3 more}
doaj   +1 more source

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

Nature and Science of Sleep, 2022
Yu-Chin An,1 Chia-Lin Tsai,2 Chih-Sung Liang,3 Yu-Kai Lin,2 Guan-Yu Lin,2 Chia-Kuang Tsai,2 Yi Liu,2 Sy-Jou Chen,1 Shih-Hung Tsai,1 Kuo-Sheng Hung,4 Fu-Chi Yang2 1Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical ...
An YC, Tsai CL, Liang CS, Lin YK, Lin GY, Tsai CK, Liu Y, Chen SJ, Tsai SH, Hung KS, Yang FC   +10 more
doaj  

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

A Nested Association Mapping Panel in Arabidopsis thaliana for Mapping and Characterizing Genetic Architecture

G3: Genes, Genomes, Genetics, 2020
Linkage and association mapping populations are crucial public resources that facilitate the characterization of trait genetic architecture in natural and agricultural systems.
Marcus T. Brock, Matthew J. Rubin, Dean DellaPenna, Cynthia Weinig   +3 more
doaj   +1 more source

The contribution of non-coding regulatory elements to cardiovascular disease [PDF]

Open Biology, 2020
Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate
Diego Villar, Stephanie Frost, Panos Deloukas, Andrew Tinker   +3 more
doaj   +1 more source

lanec-unifesspa/gwas-pd: Datapackage: Exploratory analysis of GWAS metanalyses of panic disorder

, 2017
Data packages for the research project "Exploratory analyses of GWAS data on ...
Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff"
core   +1 more source