Results 71 to 80 of about 198,268 (313)

Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling

, 2011
Genome-wide association studies (GWAS) have identified SNPs associated with breast cancer. However, they offer limited insights about the biological mechanisms by which SNPs confer risk.
Chindo Hicks, Lucio Miele, Antonio Pannuti   +2 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

mfrtn88/GWAS-analysis: Multi trait GWAS analysis

<p>R script for running multi-trait GWAS using summary stat results</p ...
Genomic_Analysis
core   +1 more source

GWAS case studies in wheat

, 2022
With the advancements in next-generation sequencing technologies, leading to millions of single nucleotide polymorphisms in all crop species including wheat, genome-wide association study (GWAS) has become a leading approach for trait dissection.
Sehgal, Deepmala, Dreisigacker, Susanne
core  

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

GWAS studies included.

, 2022
GWAS studies included.
Azmeraw T. Amare (13970102), Ellie Lawrence-Wood (12635612), Eugene Aidman (45095), M. Catharine Jawahar (13970105), K. Oliver Schubert (4268521), Natalie T. Mills (13970108), Liliana G. Ciobanu (13970099), Matthew Knight (4798383), Lazar Stankov (682857), Scott R. Clark (4268533)   +9 more
core   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

Five Years of GWAS Discovery [PDF]

The American Journal of Human Genetics, 2012
The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide ...
Visscher, P, Visscher, P, Brown, M, McCarthy, M, McCarthy, M, Yang, J   +5 more
openaire   +7 more sources

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Gwas Height.txt

, 2019
Gwas Height ...
Marion Orsucci (3201441), Bo Karlsson (600710), Chen, Jun, Li, Lili, Jun Chen (4238), Lascoux, Martin, Lili Li (42450), Gunnar Jansson (4321342), Martin Lascoux (201001), Milesi, Pascal, Pascal Milesi (474716), Berlin, Mats, Karlsson, Bo, Mats Berlin (7143071), Jansson, Gunnar, Orsucci, Marion   +15 more
core   +1 more source