Results 71 to 80 of about 191,618 (313)
SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet
Advanced Science, EarlyView.SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv +13 more
wiley +1 more source
Fine-mapping cis-regulatory variants in diverse human populations
eLife, 2019 Genome-wide association studies (GWAS) are a powerful approach for connecting genotype to phenotype. Most GWAS hits are located in cis-regulatory regions, but the underlying causal variants and their molecular mechanisms remain unknown.
Ashley Tehranchi +6 more
doaj +1 more source
mfrtn88/GWAS-analysis: Multi trait GWAS analysis
<p>R script for running multi-trait GWAS using summary stat results</p ...
Genomic_Analysis
core +1 more source
Pairwise colocalization of GWAS signals at chr7q32.2.
, 2021 (A) LocusCompare plot of chr7q32.2 locus variants’ -log10(P) from BMI GWAS versus T2D (BMI-adjusted) GWAS. Points are colored according to the variant’s r2 with the reference variant, which is marked by the purple diamond. Posterior probability (PP) of a
Jason W. Hoskins (11726336) +7 more
core +1 more source
Advanced Science, EarlyView.Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang +16 more
wiley +1 more source
Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling
, 2011 Genome-wide association studies (GWAS) have identified SNPs associated with breast cancer. However, they offer limited insights about the biological mechanisms by which SNPs confer risk.
Chindo Hicks +2 more
core +1 more source
, 2023 (A) GWAS p-value histogram and (B) Manhattan plots for the four GWAS. Genome-wide significance level (−log10(5 × 10−8)) is indicated by the red line.
Dongjun Chung (213776) +4 more
core +1 more source
Advanced Science, EarlyView.Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li +23 more
wiley +1 more source
A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency
eLife, 2020 N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears.
Dana M Talsness +11 more
doaj +1 more source
Advanced Science, EarlyView.A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma +11 more
wiley +1 more source