Results 81 to 90 of about 198,268 (313)
Advanced Science, EarlyView.A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu +13 more
wiley +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
nf-gwas - Performing highly parallelized and reproducible GWAS analysis on biobank-scale data
<h2>What's Changed</h2> <ul> <li>Update nf-test to v0.8.2 by @AmstlerStephan in https://github.com/genepi/nf-gwas/pull/91</li> <li>Integration of VCF and BGEN for gene-based testing by @filosi in https://github.com ...
Forer, Lukas, Schönherr, Sebastian
core +1 more source
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin +6 more
wiley +1 more source
Association Between Endometritis and Endometrial Polyp: A Mendelian Randomization Study
International Journal of Women's Health, 2023 Longlong Wei,1,2 Yan Zhao,2 Siyue Xu,2 Cuilian Zhang1,2 1Department of Reproductive Medicine Center, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Reproductive Medicine Center, Henan Provincial ...
Wei L, Zhao Y, Xu S, Zhang C
doaj
Haplotypes-based genetic analysis: benefits and challenges
Вавиловский журнал генетики и селекции, 2019 The increasing availability of Single Nucleotide Polymorphisms (SNPs) discovered by Next Generation Sequencing will enable a range of new genetic analyses in crops, which was not possible before.
D. Sehgal, S. Dreisigacker
doaj +1 more source
Silencing of CCR4-NOT complex subunits affects heart structure and function
Disease Models & Mechanisms, 2020 The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous.
Lisa Elmén +13 more
doaj +1 more source
Common loci verified by GWAS, RIL, and IL datasets (using GWAS LOD ≥ 5.3)
, 2016 Common loci verified by GWAS, RIL, and IL datasets (using GWAS LOD ≥ 5.3)
Yariv Brotman (390035) +9 more
core +1 more source
Pairwise colocalization of GWAS signals at chr7q32.2.
, 2021 (A) LocusCompare plot of chr7q32.2 locus variants’ -log10(P) from BMI GWAS versus T2D (BMI-adjusted) GWAS. Points are colored according to the variant’s r2 with the reference variant, which is marked by the purple diamond. Posterior probability (PP) of a
Jason W. Hoskins (11726336) +7 more
core +1 more source