Results 81 to 90 of about 241,345 (301)

Give GWAS a Chance [PDF]

Diabetes, 2017
From 2007 to 2015, genome-wide association studies (GWAS) resulted in the discovery of over 260 genetic loci associated with obesity and type 2 diabetes (T2D) (1,2). Although GWAS have validated “old culprits” (e.g., PPARG , KCNJ11 ), illuminated novel disease-causing biological pathways (e.g., the zinc transporter SLC30A8 ), and have led to quick ...
openaire   +2 more sources

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

G3: Genes, Genomes, Genetics, 2020
There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross ...
Xinzhu Zhou, Celine L. St. Pierre, Natalia M. Gonzales, Jennifer Zou, Riyan Cheng, Apurva S. Chitre, Greta Sokoloff, Abraham A. Palmer   +7 more
doaj   +1 more source

تجزیه و تحلیل غنی سازی مجموعه های ژنی با استفاده از مطالعه گسترده پویش ژنوم برای شناسایی ژن ها و مسیرهای زیستی مرتبط با دوقلوزایی در گوسفند بلوچی [PDF]

تحقیقات تولیدات دامی, 2019
گوسفند بلوچی یکی از نژادهای بومی ایران است که از شرق کشور منشا گرفته و با شرایط آب و هوایی آن منطقه سازگار شده است. بازده اقتصادی اصلاح نژاد گوسفند به طور واضحی با بازده تولیدمثل میش­ها مرتبط است. در این پژوهش، صفت دوقلوزایی به عنوان یک صفت تولیدمثلی مهم
سید مهدی اسماعیلی فرد, سید حسن حافظیان, محسن قلی زاده, رستم عبدالهی آرپناهی   +3 more
doaj   +1 more source

GWAS Matrix

, 2021
GWAS Matrix: Contain all the GWAS results with the input phenotype (coordinates of pseudo-SNPs) and all the GWAS SNPs p-value detected.
openaire   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Genome-wide association study for anther length in some elite bread wheat germplasm

Czech Journal of Genetics and Plant Breeding, 2018
The anther is a crucial organ for the development of the spike in bread wheat (Triticum aestivum L.). Long anthers contain large amounts of pollen grains; thus, they are favourable for cross-pollination and increase resilience against adverse ...
Xiaopeng SONG, Jie FENG, Zixia CUI, Chuanliang ZHANG, Daojie SUN   +4 more
doaj   +1 more source

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. [PDF]

, 2014
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene ...
Aida K. Dieffenbach, Alexander Hein, Alfons Meindl, Alison M. Dunning, Amanda B. Spurdle, Angel Carracedo, Angela Cox, Angela Jones, Anja Rudolph, Anjali K. Henders, Anne-Lise Børresen-Dale, Annika Lindblom, Anthony J. Swerdlow, Arif B. Ekici, Attila Teoman, Augusto Rojas-Martinez, Bach, Bahcall, Barbara Burwinkel, Berndt, Boris Winterhoff, Brooke L. Fridley, Buchanan, Buchner, Cancer Genome Atlas Research Network, Cancer Genome Atlas Research, N, Carina Walpole, Catherine S. Healey, Cerami, Cuff, Dale R. Nyholt, Deborah J. Thompson, Diether Lambrechts, Douglas F. Easton, Dunham, Edwards, Eeles, Eeles, Eger, Elizabeth Holliday, Ellen L. Goode, Emma Tham, Erika Santos, Felicity A. Lose, Fergus J. Couch, Ferreira, Fiona Bruinsma, Frederic Amant, Frederik Marme, Gao, Garcia-Closas, Garg, Gauderman, Geoffrey Otton, Gerasimos Tzortzatos, Glinsky, Graham G. Giles, Grant W. Montgomery, Grisanzio, Gudmundsson, Harries, Helga B. Salvesen, Henrica M.J. Werner, Hermann Brenner, Higgins, Hiltrud Brauch, Houlston, Howie, Howie, Hughes, Ian Tomlinson, Ingo Runnebaum, Janet E. Olson, Jenny Chang-Claude, Jeroen Depreeuw, Jianjun Liu, Jingmei Li, Jirong Long, Jodie N. Painter, Joe Dennis, John Attia, John L. Hopper, Jonathan P. Tyrer, Jone Trovik, Julian Peto, Julie M. Cunningham, Juliet D. French, Jyotsna Batra, Kaltin Ferguson, Kamila Czene, Katie Ashton, Kimberley Howarth, Kristine M. Hillman, Kyriaki Michailidou, Lazarevich, Leire Moya, Lieve Coenegrachts, Liu, Long, Luis Carvajal-Carmona, Lynn Martin, Ma. Magdalena Echeverry De Polanco, Macintyre, Maggie Gorman, Manjeet K. Bolla, Manuel R. Teixeira, Mark McEvoy, Matthias Dürst, Matthias Ruebner, Matthias W. Beckmann, Matthieu Moisse, McEvoy, McGregor, Melissa C. Southey, Michailidou, Miriam Mints, Mitul Shah, Monica Sans, Nicholas G. Martin, Nicholas Orr, Nicola Johnson, Painter, Pamela Pollock, Paul D.P. Pharoah, Penelope M. Webb, Per Hall, Peter A. Fasching, Peter Hillemanns, Pharoah, Pruim, Qin Wang, Rachel Palmieri Weber, Rodney J. Scott, Sakoda, Sean C. Dowdy, Sergi Castellvi-Bel, Shahana Ahmed, Shao, Shen, Shirley Hodgson, Singh, Spoelstra, Spurdle, Stacey L. Edwards, Stefan P. Renner, Stefanie Schrauwen, Sun, Susanne Kaufmann, Takata, Tavassoli, Teo, Terasawa, Thilo Dörk, Thomas, Timothy Cheng, Tony Proietto, Tormund S. Njolstad, Tracy A. O'Mara, Tsuchiya, Udler, Vessela N. Kristensen, Wei Zheng, Wellcome Trust Case Control Consortium, Xiao-Ou Shu, Yong-Bing Xiang, Zhihua Chen   +165 more
core   +7 more sources

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle

Czech Journal of Animal Science, 2018
The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for the presence of genes that may affect milk production traits in Portuguese Holstein cattle.
Mohamed Mahmoud Ibrahim Salem, Gertrude Thompson, Shanyuan Chen, Albano Beja-Pereira, Julio Carvalheira   +4 more
doaj   +1 more source