Results 81 to 90 of about 191,618 (313)
Five Years of GWAS Discovery [PDF]
The American Journal of Human Genetics, 2012 The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide ...
Visscher, P +5 more
openaire +7 more sources
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
, 2022 With the advancements in next-generation sequencing technologies, leading to millions of single nucleotide polymorphisms in all crop species including wheat, genome-wide association study (GWAS) has become a leading approach for trait dissection.
Sehgal, Deepmala, Dreisigacker, Susanne
core +1 more source
G3: Genes, Genomes, Genetics, 2020 There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross ...
Xinzhu Zhou +7 more
doaj +1 more source
تجزیه و تحلیل غنی سازی مجموعه های ژنی با استفاده از مطالعه گسترده پویش ژنوم برای شناسایی ژن ها و مسیرهای زیستی مرتبط با دوقلوزایی در گوسفند بلوچی [PDF]
تحقیقات تولیدات دامی, 2019 گوسفند بلوچی یکی از نژادهای بومی ایران است که از شرق کشور منشا گرفته و با شرایط آب و هوایی آن منطقه سازگار شده است. بازده اقتصادی اصلاح نژاد گوسفند به طور واضحی با بازده تولیدمثل میشها مرتبط است. در این پژوهش، صفت دوقلوزایی به عنوان یک صفت تولیدمثلی مهم
سید مهدی اسماعیلی فرد +3 more
doaj +1 more source
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Genome-wide association study for anther length in some elite bread wheat germplasm
Czech Journal of Genetics and Plant Breeding, 2018 The anther is a crucial organ for the development of the spike in bread wheat (Triticum aestivum L.). Long anthers contain large amounts of pollen grains; thus, they are favourable for cross-pollination and increase resilience against adverse ...
Xiaopeng SONG +4 more
doaj +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source