Results 81 to 90 of about 174,316 (315)
A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency
eLife, 2020 N-Glycanase 1 (NGLY1) is a cytoplasmic deglycosylating enzyme. Loss-of-function mutations in the NGLY1 gene cause NGLY1 deficiency, which is characterized by developmental delay, seizures, and a lack of sweat and tears.
Dana M Talsness +11 more
doaj +1 more source
Five Years of GWAS Discovery [PDF]
The American Journal of Human Genetics, 2012 The past five years have seen many scientific and biological discoveries made through the experimental design of genome-wide association studies (GWASs). These studies were aimed at detecting variants at genomic loci that are associated with complex traits in the population and, in particular, at detecting associations between common single-nucleotide ...
Visscher, P +5 more
openaire +7 more sources
The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton
Advanced Science, EarlyView.Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang +32 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2020 There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross ...
Xinzhu Zhou +7 more
doaj +1 more source
تجزیه و تحلیل غنی سازی مجموعه های ژنی با استفاده از مطالعه گسترده پویش ژنوم برای شناسایی ژن ها و مسیرهای زیستی مرتبط با دوقلوزایی در گوسفند بلوچی [PDF]
تحقیقات تولیدات دامی, 2019 گوسفند بلوچی یکی از نژادهای بومی ایران است که از شرق کشور منشا گرفته و با شرایط آب و هوایی آن منطقه سازگار شده است. بازده اقتصادی اصلاح نژاد گوسفند به طور واضحی با بازده تولیدمثل میشها مرتبط است. در این پژوهش، صفت دوقلوزایی به عنوان یک صفت تولیدمثلی مهم
سید مهدی اسماعیلی فرد +3 more
doaj +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Cognitive behavioral therapy (CBT) is a well‐established, evidence‐based treatment for common mental disorders such as depression, anxiety disorders, and obsessive‐compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement.
Julia Bäckman +41 more
wiley +1 more source
Genome-wide association study for anther length in some elite bread wheat germplasm
Czech Journal of Genetics and Plant Breeding, 2018 The anther is a crucial organ for the development of the spike in bread wheat (Triticum aestivum L.). Long anthers contain large amounts of pollen grains; thus, they are favourable for cross-pollination and increase resilience against adverse ...
Xiaopeng SONG +4 more
doaj +1 more source
Overlap of GWAS signals for birth weight GWAS and childhood obesity GWAS.
, 2019 Overlap of GWAS signals for birth weight GWAS and childhood obesity GWAS.
Maya A. Deyssenroth (4114159) +11 more
core +1 more source