Results 101 to 110 of about 174,316 (315)

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

, 2011
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium.
Psychiatric, GWAS Consortium Bipolar Disorder Working Group
core   +2 more sources

The IIIVmrMLM method uncovers new genetic variants associated with resistance to Fusarium wilt in flax

Вавиловский журнал генетики и селекции
Flax (Linum usitatissimum) is an important agricultural crop grown for fiber and oil production, playing a key role in various industries such as production of paints, linoleum, food, clothes and composite materials.
M. A. Duk, A. A. Kanapin, A. A. Samsonova, M. P. Bankin, M. G. Samsonova   +4 more
doaj   +1 more source

Principles for the post-GWAS functional characterisation of risk loci

, 2010
Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3.
Chris Carlson, Ian Mills, Christoph Plass, Michael James, Graham Casey, Haris Vikis, Matthew L. Freedman, Jay W. Tichelaar, Simon Gayther, Ming You, Pengyuan Liu, Ian G. Mills, Alvaro N. A. Monteiro, Haris G. Vikis, Gerhard Coetzee, Matthew Freedman, Gerhard A. Coetzee, Dave Duggan, Angela Risch, Mariella De Biasi, Alvaro Monteiro, Jay Tichelaar, Simon A. Gayther   +22 more
core   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Flax transposons: unraveling their impact on domestication and agronomic trait variation

Вавиловский журнал генетики и селекции
Flax is an important agricultural crop with multifunctional uses. Diversified breeding for oil content in seeds and fiber in stems has led to the emergence of two morphotypes – fiber flax and oilseed flax.
M. A. Duk, V. A. Stanin, A. A. Kanapin, A. A. Samsonova, T. A. Rozhmina, M. G. Samsonova   +5 more
doaj   +1 more source

GWAS case studies in wheat

, 2022
With the advancements in next-generation sequencing technologies, leading to millions of single nucleotide polymorphisms in all crop species including wheat, genome-wide association study (GWAS) has become a leading approach for trait dissection.
Sehgal, Deepmala, Dreisigacker, Susanne
core  

Beyond the GWAS in schizophrenia

EMBO Molecular Medicine, 2011
The identification of the genetic factors that influence susceptibility to neuropsychiatric illness has proven challenging. Currently, several approaches are being utilized to enhance the potential of these studies. Most commonly, a ‘discovery’ genome wide association study (GWAS) with a focus on a single clinical diagnostic group such as schizophrenia,
openaire   +2 more sources

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis

Nature and Science of Sleep
Wanqing Lin,1,2,* Zhiyi Zhang,3,* Chenlin Wang,4 Yingling Ye,4 Lingrong Zheng,4 Qianqian Hu,4 Renyu Yu,1 Mingxia Wu,4,5 Bin Chen1 1Department of Rehabilitation Medicine and National Clinical Research Base of Traditional Chinese Medicine, The ...
Lin W, Zhang Z, Wang C, Ye Y, Zheng L, Hu Q, Yu R, Wu M, Chen B   +8 more
doaj