Results 91 to 100 of about 198,268 (313)
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou +13 more
wiley +1 more source
CCADS-GWAS-Genetic polymorphisms
We performed genome-wide association study (GWAS) and computed polygenic risk score (PRS) to explore the genetic susceptibility factors and prediction model of cerebral artery dissection based on Shanghai Huashan Hospital cases.
Xiang Han (18171097)
core +1 more source
Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu +12 more
wiley +1 more source
Advanced Science, EarlyView.Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin +9 more
wiley +1 more source
MAGMA GWAS files from GWAS Atlas
, 2019 MAGMA gene-based p-values from GWAS ...
Gokcen Eraslan (7407296)
core +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
Genetic aspects of non-alcoholic fatty liver disease development
Лечащий Врач, 2021 Progression of non-alcoholic fatty liver disease (NAFLD) is conditioned by genetic susceptibility, environmental factors, lifestyle and features of the metabolic syndrome, many of which overlap with hepatocellular carcinoma.
V. A. Akhmedov, T. I. Melikov
doaj
Advanced Science, EarlyView.Subcellular spatial transcriptomics enables high‐resolution mapping of gene expression within tissues, but accurate cell segmentation is essential for assigning transcripts to individual cells. We present SpaCut, a deep learning framework that integrates transcriptomic features with nucleus‐guided morphological information to precisely delineate cell ...
Yongheng Li, Fangfang Zhu, Wenwen Min
wiley +1 more source