Results 91 to 100 of about 191,618 (313)

Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle

Czech Journal of Animal Science, 2018
The objectives of this study were to estimate linkage disequilibrium (LD), describe and scan a haplotype block for the presence of genes that may affect milk production traits in Portuguese Holstein cattle.
Mohamed Mahmoud Ibrahim Salem, Gertrude Thompson, Shanyuan Chen, Albano Beja-Pereira, Julio Carvalheira   +4 more
doaj   +1 more source

CCADS-GWAS-Genetic polymorphisms

We performed genome-wide association study (GWAS) and computed polygenic risk score (PRS) to explore the genetic susceptibility factors and prediction model of cerebral artery dissection based on Shanghai Huashan Hospital cases.
Xiang Han (18171097)
core   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

A Two-Stage Mutual Information Based Bayesian Lasso Algorithm for Multi-Locus Genome-Wide Association Studies

Entropy, 2020
Genome-wide association study (GWAS) has turned out to be an essential technology for exploring the genetic mechanism of complex traits. To reduce the complexity of computation, it is well accepted to remove unrelated single nucleotide polymorphisms ...
Hongping Guo, Zuguo Yu, Jiyuan An, Guosheng Han, Yuanlin Ma, Runbin Tang   +5 more
doaj   +1 more source

nf-gwas - Performing highly parallelized and reproducible GWAS analysis on biobank-scale data

<h2>What's Changed</h2> <ul> <li>Update nf-test to v0.8.2 by @AmstlerStephan in https://github.com/genepi/nf-gwas/pull/91</li> <li>Integration of VCF and BGEN for gene-based testing by @filosi in https://github.com ...
Forer, Lukas, Schönherr, Sebastian
core   +1 more source

Overlap of GWAS signals for birth weight GWAS and childhood obesity GWAS.

, 2019
Overlap of GWAS signals for birth weight GWAS and childhood obesity GWAS.
Maya A. Deyssenroth (4114159), Arno Ruusalepp (225250), Carmen J. Marsit (109106), Haoxiang Cheng (4821396), Johan L. M. Bjorkegren (6167309), Jason C. Kovacic (3280764), Shouneng Peng (493132), Zhongyang Zhang (828677), Luca Lambertini (72724), Jia Chen (8203), Antonio F. Di Narzo (3700774), Ke Hao (50181)   +11 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Details of GWAS used as outcomes.

, 2022
IEUGWAS id: study ID in the IEU GWAS database, Outcome trait: name of the GWAS trait, Cohort: name of the GWAS cohort, Sex: sex of the GWAS population, Population: ethnicity of the GWAS population, Unit: measurement unit of the GWAS trait, Sample size ...
Joey Ward (3825244), Nicholas Graham (815122), Donald M. Lyall (7783649), Breda Cullen (489583), Eric A. W. Slob (11654664), Naveed Sattar (8785), Alisha Aman (12261387), Rona J. Strawbridge (7718663)   +7 more
core   +1 more source