Results 61 to 70 of about 133,124 (219)

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

PaDSPD, a MYB-like transcription factor is linked with the diurnally synchronized protogynous dichogamy flowering type in avocado

Fruit Research
Avocado (Persea americana) exhibits a distinctive flowering pattern known as diurnally synchronous protogynous dichogamy (DSPD), in which flowers of Type A cultivars open as female in the morning on day one and as male in the afternoon on day two, while ...
Adil Khan, Shamseldeen Eltaher, Barbie Freeman, Gul Shad Ali   +3 more
doaj   +1 more source

Osteoporosis- and obesity-risk interrelationships: an epigenetic analysis of GWAS-derived SNPs at the developmental gene TBX15

Epigenetics, 2020
A major challenge in translating findings from genome-wide association studies (GWAS) to biological mechanisms is pinpointing functional variants because only a very small percentage of variants associated with a given trait actually impact the trait. We
Xiao Zhang, Kenneth C. Ehrlich, Fangtang Yu, Xiaojun Hu, Xiang-He Meng, Hong-Wen Deng, Hui Shen, Melanie Ehrlich   +7 more
doaj   +1 more source

Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices

Nature and Science of Sleep
Ahmed S BaHammam,1,2 Haitham Jahrami3,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia ...
BaHammam AS, Jahrami H
doaj  

“It's Not Deterministic and It Will Never Be Deterministic”: A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post‐Traumatic Stress Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Post‐traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest.
Brandy M. Fox
wiley   +1 more source

Assessment of Genetic Correlations Between Tobacco or Alcohol Use and Neurodegenerative Diseases Using East Asian Genetic Ancestry Genome‐Wide Association Study Results

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent late‐onset neurodegenerative diseases worldwide. Both are influenced in part by genetic factors and are currently incurable. Tobacco and alcohol, the two most common substances used among the general adult population, are potential AD/PD risk factors and are also ...
Linda Wang, Wiame Belbellaj, Frida Lona‐Durazo, Sarah A. Gagliano Taliun   +3 more
wiley   +1 more source

Association Between Serum Copper and COPD: Insights from NHANES 2011-2016 and Mendelian Randomization Study

Tobacco Induced Diseases
Introduction Chronic obstructive pulmonary disease (COPD) affects 390 million people globally, with oxidative stress playing a key pathogenic role. Smoking and other forms of tobacco exposure are major COPD drivers and important sources of systemic ...
Jiajia Qu, Mengyu Zhang, Chenyang Hu, Yongli Liu, Wei Zhao, Yiqing Qu   +5 more
doaj   +1 more source

Maximum difference analysis: a new empirical method for genome-wide association studies

Italian Journal of Animal Science, 2016
The availability of high-density single nucleotide polymorphism (SNPs) panels for humans and, recently, for several livestock species has given a great impulse to genome-wide association studies towards the identification of genes associated with complex
Massimo Cellesi, Corrado Dimauro, Silvia Sorbolini, Ezequiel Luis Nicolazzi, Giustino Gaspa, Paolo Ajmone-Marsan, Nicolò Pietro Paolo Macciotta   +6 more
doaj   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Rpv34: the noval Plasmopara viticola resistance locus in 'Moldova'

Fruit Research
Downy mildew (DM), caused by Plasmopara viticola, is one of the most serious diseases that affects grape production worldwide. Utilizing host resistance, commonly known as 'R' genes, is considered the most effective way to cure the disease.
Yan Sun, Bohan Yang, Minmin Li, Changjiang Liu, Yonggang Yin, Nan Jia, Xinyu Wang, Qingming Zeng, Yong Guo, Yingjie Wang, Guohong Wu, Qinqin Gu, Jianfeng Lou, Peining Fu, Bin Han   +14 more
doaj   +1 more source