Results 61 to 70 of about 174,316 (315)
A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits [PDF]
, 2022 Infectious diseases are particularly challenging for genome-wide association studies (GWAS) because genetic effects from two organisms (pathogen and host) can influence a trait.
Hirsch, Hans H. +38 more
core +1 more source
Diabetes, 2017 From 2007 to 2015, genome-wide association studies (GWAS) resulted in the discovery of over 260 genetic loci associated with obesity and type 2 diabetes (T2D) (1,2). Although GWAS have validated “old culprits” (e.g., PPARG , KCNJ11 ), illuminated novel disease-causing biological pathways (e.g., the zinc transporter SLC30A8 ), and have led to quick ...
openaire +2 more sources
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
, 2019 <p>gwas test-2: two more files uploaded together</p ...
Dongbo Hu, Dongbo Hu (4612015)
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Pairwise colocalization of GWAS signals at chr7q32.2.
, 2021 (A) LocusCompare plot of chr7q32.2 locus variants’ -log10(P) from BMI GWAS versus T2D (BMI-adjusted) GWAS. Points are colored according to the variant’s r2 with the reference variant, which is marked by the purple diamond. Posterior probability (PP) of a
Jason W. Hoskins (11726336) +7 more
core +1 more source
Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean
Advanced Science, EarlyView.This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma +11 more
wiley +1 more source
Blood, 2015 In this issue of Blood , [Sato-Otsubo et al][1] perform a genome-wide association study (GWAS) to identify minor histocompatibility antigens associated with clinically relevant graft-versus-host disease (GVHD).[1][2] ![Figure][3] Schematic representation of different factors influencing ...
openaire +2 more sources
Advanced Science, EarlyView.ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu +5 more
wiley +1 more source