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Blastic plasmacytoid dendritic cell neoplasm. A rare hematodermic malignancy
Hematology, Transfusion and Cell Therapy, 2020 Deepa Goel, Rahul Bhargava
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Blastic Plasmacytoid Dendritic Cell Neoplasm
Journal of the National Comprehensive Cancer Network, 2023Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with an aggressive clinical course and poor prognosis. BPDCN is most often characterized by its presentation with distinct cutaneous lesions. Bone marrow involvement, lymphadenopathy, splenomegaly, and/or cytopenias are also seen to varying degrees.
Akriti, Jain, Kendra, Sweet
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Blastic Plasmacytoid Dendritic Cell Neoplasm
The American Journal of Dermatopathology, 2021Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that frequently has cutaneous manifestations. The diagnosis can be a challenge because of its heterogenous clinical presentation, ranging from a brown or violaceous solitary nodule or patch to mixed, disseminated lesions.
Ather, Adnan +4 more
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Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm
Hematology/Oncology Clinics of North America, 2020Tagraxofusp, a CD123-targeted immunotoxin, is the first FDA-approved treatment for patients 2 years and older with blastic plasmacytoid dendritic cell neoplasm (BPDCN). It has been shown to be safe and effective in treatment-naïve and previously treated adult patients, with high rates of successful bridging to hematopoietic stem cell transplantation ...
Danielle, Hammond, Naveen, Pemmaraju
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Blastic Plasmacytoid Dendritic Cell Neoplasm in Children
Hematology/Oncology Clinics of North America, 2020Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematological malignancy, derived from plasmacytoid dendritic cells. It mainly occurs in older adults, but has been reported across all age groups. Most patients present with skin lesions with or without marrow involvement and leukemic dissemination.
Yixian, Li +3 more
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Blastic Plasmacytoid Dendritic Cell Neoplasm
2017Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignant neoplasm originating from precursor plasmacytoid dendritic cells. Blastic plasmacytoid dendritic cell neoplasm shows a characteristic immunophenotype in which the tumor cells express CD4, CD56, TCL1, and bright CD123, and lack expression of lineage-specific myeloid and lymphoid ...
Michael J. Cascio, Robert S. Ohgami
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More on Blastic Plasmacytoid Dendritic-Cell Neoplasms
New England Journal of Medicine, 2019Jean-Baptiste, Micol +2 more
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