Results 191 to 200 of about 147,588 (334)

Potential cytotoxicity of truncated slow skeletal muscle troponin T (ssTnT) in a loss of function TNNT1 myopathy mouse model

open access: yesThe FEBS Journal, Volume 292, Issue 20, Page 5525-5539, October 2025.
A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng   +2 more
wiley   +1 more source

Adsorption of antigen to polymeric nanoparticles enhances cytotoxic T‐cell responses and anti‐tumor immunity by targeting conventional type 1 dendritic cells

open access: yesImmunology &Cell Biology, Volume 103, Issue 9, Page 825-843, October 2025.
Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco   +6 more
wiley   +1 more source

The initial report of prospective study for maternal and fetal outcomes to investigate the safety of multifetal pregnancy reduction in Japan

open access: yesJournal of Obstetrics and Gynaecology Research, Volume 51, Issue 10, October 2025.
Abstract Aim This study aimed to establish the safety of multifetal pregnancy reduction (MFPR) and examine its complications, patient background, and psychological impact. Methods This single‐center, single‐arm, prospective intervention study included 10 women who were treated at our institution between April and December 2024.
Nao Wakui   +8 more
wiley   +1 more source

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