Results 211 to 220 of about 133,185 (340)

Single‐Cell Analysis of Alternative Splicing and Gene Regulatory Network Reveals Remarkable Expression and Regulation Dynamics During Human Early Embryonic Development

open access: yesFASEB BioAdvances, Volume 7, Issue 7, July 2025.
By integrating single‐cell RNA‐seq data, this study reveals dynamic changes in gene expression, alternative splicing, and isoform switching during human early embryonic development (E3–E7). These regulatory layers are complementary and stage‐specific, with sex‐dependent differences especially evident at E3.
Jiwei Chen   +5 more
wiley   +1 more source

Cathepsin B Regulates Ovarian Reserve Quality and Quantity via Mitophagy by Modulating IGF1R Turnover

open access: yesAging Cell, Volume 24, Issue 7, July 2025.
Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility,
Aradhana Mohanty   +8 more
wiley   +1 more source

Blastocyst vs cleavage‐stage embryo transfer: systematic review and meta‐analysis of reproductive outcomes

open access: yesUltrasound in Obstetrics and Gynecology, 2017
Wellington P. Martins   +6 more
semanticscholar   +1 more source

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

open access: yesAndrology, Volume 13, Issue 5, Page 1137-1148, July 2025.
Abstract Background Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development. Disruptions in the piRNA pathway typically lead to severe spermatogenic defects and thus male infertility. The HENMT1 gene is a key player in piRNAs
Zeina Wehbe   +17 more
wiley   +1 more source

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