Results 81 to 90 of about 122,819 (363)
Nature Communications, 2016 Intercellular communication is essential to coordinate the behaviour of individual cells during organismal development. The preimplantation mammalian embryo is a paradigm of tissue self-organization and regulative development; however, the cellular basis
Néstor Saiz +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source
Ultrasound in Obstetrics and Gynecology, 2017 Blastocyst transfer in assisted reproduction techniques could be advantageous because the timing of exposure of the embryo to the uterine environment is more analogous to a natural cycle and permits embryo self‐selection after activation of the embryonic
Wellington P. Martins +6 more
semanticscholar +1 more source
NF2 is Essential for Human Endoderm Development
Advanced Science, EarlyView.This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong +5 more
wiley +1 more source
The Quiet Embryo Hypothesis: 20 years on
Frontiers in Physiology, 2022 This article revisits the hypothesis, proposed in 2002, that the successful development of oocytes and preimplantation mammalian embryos is associated with a metabolism which is “quiet” rather than “active”, within limits which had yet to be defined.
Henry J. Leese +4 more
doaj +1 more source
Deep learning mediated single time-point image-based prediction of embryo developmental outcome at the cleavage stage [PDF]
arXiv, 2020 In conventional clinical in-vitro fertilization practices embryos are transferred either at the cleavage or blastocyst stages of development. Cleavage stage transfers, particularly, are beneficial for patients with relatively poor prognosis and at fertility centers in resource-limited settings where there is a higher chance of developmental failure in ...
arxiv
Genetic Normalization of Differentiating Aneuploid Human Embryos [PDF]
, 2011 Early embryogenesis involves a series of dynamic processes, many of which are currently not well described or understood. Aneuploidy and aneuploid mosaicism, a mixture of aneuploid and euploid cells within one embryo, in early embryonic development are ...
Andrew Barker +8 more
core +1 more source
Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts [PDF]
, 2017 During the transit through the oviduct, the early embryo initiates an extensive DNA methylation reprogramming of its genome. Given that these epigenetic modifications are susceptible to environmental factors, components present in the oviductal milieu ...
Barrera, Antonio Daniel +7 more
core +1 more source
Human Reproduction, 2017 STUDY QUESTION Does the amount of mitochondrial DNA (mtDNA) in blastocyst biopsy specimens have the potential to serve as a biomarker of euploid embryo implantation ability, independent of morphology?
K. Ravichandran +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.DPImpute is a two‐step pipeline that outperforms existing tools in whole‐genome SNP imputation, particularly under conditions of ultra‐low coverage sequencing, small sample sizes, and limited references. It enables precise imputation for single blastocyst cells, supporting genomic selection at the pre‐implantation stage.
Weigang Zheng +11 more
wiley +1 more source