Results 91 to 100 of about 1,947,962 (285)
A surface finite element method for computational modelling of cell blebbing [PDF]
arXiv, 2020 Cell blebs are protrusions of the cell membrane and can be instrumental for cell migration. We derive a continuum model for the mechanical and geometrical aspects of the onset of blebbing in terms of a force balance. It is abstract and flexible in that it allows for amending force contributions related to membrane tension or the presence of linker ...
arxiv
Getting in shape and swimming: the role of cortical forces and membrane heterogeneity in eukaryotic cells [PDF]
Journal of Mathematical Biology (2018), 2017 Recent research has shown that motile cells can adapt their mode of propulsion to the mechanical properties of the environment in which they find themselves--crawling in some environments while swimming in others. The latter can involve movement by blebbing or other cyclic shape changes, and both highlysimplified and more realistic models of these ...
arxiv +1 more source
Unjamming Transition as a Paradigm for Biomechanical Control of Cancer Metastasis
Cytoskeleton, EarlyView.ABSTRACT Tumor metastasis is a complex phenomenon that poses significant challenges to current cancer therapeutics. While the biochemical signaling involved in promoting motile phenotypes is well understood, the role of biomechanical interactions has recently begun to be incorporated into models of tumor cell migration.
Grace Cai +2 more
wiley +1 more source
International Medical Case Reports Journal, 2015 Hideto Sagara,1,2 Tetsuju Sekiryu,2 Hiroki Noji,2 Masashi Ogasawara,2 Kimihiro Imaizumi,2 Keiko Yago31The Marui Eye Clinic, Minamisoma, 2Department of Ophthalmology, School of Medicine, Fukushima Medical University.
Sagara H +5 more
doaj
Eye &ENT Research, EarlyView.Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng +5 more
wiley +1 more source
Pirfenidone inhibits fibrosis in foreign body reaction after glaucoma drainage device implantation
Drug Design, Development and Therapy, 2016 Kyoung In Jung, Chan Kee ParkDepartment of Ophthalmology and Visual Science, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South KoreaBackground: The aim of this study was to investigate the antiscarring ...
Jung KI, Park CK
doaj
Clinical Ophthalmology, 2023 Joseph F Panarelli,1 Vanessa Vera,2 Arsham Sheybani,3 Nathan Radcliffe,4 Richard Fiscella,2 Brian A Francis,5 Oluwatosin U Smith,6 Robert J Noecker7,8 1Department of Ophthalmology, New York University, New York, NY, USA; 2Allergan, an AbbVie Company ...
Panarelli JF +7 more
doaj
A computational model of bleb formation.
Mathematical medicine and biology : a journal of the IMA, 2013 Blebbing occurs when the cytoskeleton detaches from the cell membrane, resulting in the pressure-driven flow of cytosol towards the area of detachment and the local expansion of the cell membrane.
Wanda Strychalski, R. Guy
semanticscholar +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens +3 more
wiley +1 more source
Clinical Ophthalmology, 2012 Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women's ...
Sagara H +5 more
doaj