Results 41 to 50 of about 13,955 (223)

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination

Clinical Ophthalmology, 2012
Mohammad A RashadOphthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose: To evaluate the success rate of a modified bleb needling technique in eyes with previous glaucoma surgery that had elevated intraocular pressure ...
Rashad MA
doaj  

Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading [PDF]

, 2007
Actin-based motility is central to cellular processes such as migration, bacterial engulfment, and cancer metastasis, and requires precise spatial and temporal regulation of the cytoskeleton.
Anna H. Shneidman, Benjamin J. Dubin-Thaler, Chris Wiggins, Hans-Guenther Dobereiner, Harry V. Xenias, Ingrid A. Spielman, Jake M. Hofman, Lawrence David, Michael P. Sheetz   +8 more
core   +1 more source

Paecilomyces lilacinus-induced Scleritis Following Bleb-associated Endophthalmitis after Trabeculectomy [PDF]

, 2015
Paecilomyces lilacinus (P. lilacinus) is a rare cause of fungal scleritis. We herein report a case of P. lilacinus-induced scleritis following bleb-associated endophthalmitis after trabeculectomy that was successfully treated with surgical excision of ...
Narita, Akiko, Seguchi, Jiro, Shiraga, Fumio   +2 more
core   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Factors influencing the filtration-bleb volume after Ex-PRESS® surgery

Clinical Ophthalmology, 2018
Naoki Tojo, Atsushi Hayashi, Mitsuya Otsuka Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan Purpose: The aim of this study was to investigate the factors influencing the volume of the ...
Tojo N, Hayashi A, Otsuka M
doaj  

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Treatment with sodium hyaluronate eye drops in a patient who had early-onset bleb leakage after trabeculectomy with mitomycin C

International Medical Case Reports Journal, 2015
Hideto Sagara,1,2 Tetsuju Sekiryu,2 Hiroki Noji,2 Masashi Ogasawara,2 Kimihiro Imaizumi,2 Keiko Yago31The Marui Eye Clinic, Minamisoma, 2Department of Ophthalmology, School of Medicine, Fukushima Medical University.
Sagara H, Sekiryu T, Noji H, Ogasawara M, Imaizumi K, Yago K   +5 more
doaj  

Intraluminal Deposits Found in Glaucoma Tube Shunts Via Anterior Segment Ocular Coherence Tomography [PDF]

, 2018
PURPOSE: To describe and characterize a novel observation of intraluminal deposits of glaucoma tube shunts (TS) using spectral domain (SD) ocular coherence topography (OCT).
Alvarado, Jorge A., Srivastava, Vinita, Sun, Yang   +2 more
core   +1 more source