Results 41 to 50 of about 19,247 (234)

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Clinical presentation, treatment, and outcome of 24 dogs with bacterial meningitis or meningoencephalitis without empyema (2010‐2020)

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 223-229, January/February 2023., 2023
Abstract Background Bacterial meningitis (BM) and meningoencephalitis (BMEM) are associated with high case fatality rates and neurologic sequelae in people, but limited data exists on outcome in dogs. Hypothesis/Objectives To report the clinicopathologic features, treatment and outcome of BM/BMEM in dogs, with a focus on clinical presentation, relapse ...
Faye Rawson, Max Foreman, Thomas Mignan, Jack Galer, Anne Fraser, Abbe Crawford   +5 more
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Incidence of bleb-associated endophthalmitis in the United States

Clinical Ophthalmology, 2015
Kamyar Vaziri,1 Krishna Kishor,1 Stephen G Schwartz,1 Arindel S Maharaj,1 Darius M Moshfeghi,2 Andrew A Moshfeghi,3 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL ...
Vaziri K, Kishor K, Schwartz SG, Maharaj AS, Moshfeghi DM, Moshfeghi AA, Flynn HW Jr   +6 more
doaj  

Ab Interno XEN Gel Stent Implantation in Eyes with Previous Tube Shunt Surgery

Clinical Ophthalmology, 2022
Lily Kai Man Xu,1 Toby Yiu Bong Chan2,3 1Faculty of Medicine, McMaster University, Hamilton, Ontario, Canada; 2Division of Ophthalmology, Department of Surgery, McMaster University, Waterloo Regional Campus, Kitchener-Waterloo, Ontario, Canada; 3Ocular ...
Xu LKM, Chan TYB
doaj  

Volume changes during active shape fluctuations in cells [PDF]

, 2015
Cells modify their volume in response to changes in osmotic pressure but it is usually assumed that other active shape variations do not involve significant volume fluctuations. Here we report experiments demonstrating that water transport in and out of the cell is needed for the formation of blebs, commonly observed protrusions in the plasma membrane ...
arxiv   +1 more source

Confinement by Liquid‐Liquid Interface Replicates In Vivo Neutrophil Deformations and Elicits Bleb‐Based Migration

Advanced Science, EarlyView.
Leukocytes sense mechanical cues provided by surrounding cells to regulate motility. Replicating the confining pressures applied by soft, elastic tissues in vitro is challenging. Here, the use of liquid‐liquid interfaces is introduced to model forces exerted by surrounding cells. Confining pressures are tunable by controlling interfacial curvature, and
Jonathan H. Schrope, Adam Horn, Kaitlyn Lazorchak, Clyde W. Tinnen, Jack J Stevens, Mehtab Farooqui, Tanner Robertson, Jiayi Li, David Bennin, Terry Juang, Adeel Ahmed, Chao Li, Anna Huttenlocher, David J Beebe   +13 more
wiley   +1 more source

Pyoderma Gangrenosum of the Hand: Unique Experience and Literature Review

Orthopaedic Surgery, Volume 15, Issue 1, Page 362-365, January 2023., 2023
Pyoderma gangrenosum (PG) is usually a rare disease. However, knowledge of the disease is essential to actively consider PG at an early stage to help facilitate immediate treatment and avoid unnecessary interventions that may worsen the outcome. Background Pyoderma gangrenosum (PG) is a reactive, noninfectious, neutrophilic dermatosis.
Soo‐Hwan Kang, Il‐Jung Park, Ji Won Yoo, Jong Woo Park, Hyun Woo Park, Seungbae Oh   +5 more
wiley   +1 more source

Prevention of Ocular Scarring Post Glaucoma Filtration Surgery Using the Inflammatory Cell and Platelet Binding Modulator Saratin in a Rabbit Model [PDF]

, 2012
Clinical Relevance: Late complications can occur with use of current antimetabolites to prevent scarring following glaucoma filtration surgery (GFS). Safer, more targeted, anti-fibrosis agents are sought. Objectives: The protein saratin has been shown to
A Bonnefoy, A Dugrillon, Ashley R. Beattie, BA Francis, CJ Connon, Craig A. Meyers, CS Barnes, Demetrios Vavvas, Don A. Samuelson, ED Muckley, G Schultz, G Vilahur, Gregory S. Schultz, HJ Beckers, J Burr, JA Davis, Jeff Min, JW Doyle, M Knorr, Mark B. Sherwood, MB Sherwood, MF Cordeiro, Monica A. Levine, N Anand, PF Glidden, PO Denk, PT Khaw, PT Khaw, PW DeBry, R Bindlish, S Gehring, T Meyer-ter-Vehn, TC White, TP Smith, W Gronwald, YQ Xiao, Z Li, Zachary L. Lukowski   +37 more
core   +7 more sources

Spontaneous contractility--mediated cortical flow generates cell migration in 3-dimensional environments [PDF]

, 2010
We present a generic model of cell motility generated by acto-myosin contraction of the cell cortex. We identify analytically dynamical instabilities of the cortex and show that they trigger spontaneous cortical flows which in turn can induce cell migration in 3-dimensional (3D) environments as well as bleb formation.
arxiv   +1 more source