Results 71 to 80 of about 13,955 (223)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

An emerging treatment option for glaucoma: Rho kinase inhibitors

Clinical Ophthalmology, 2014
Sean K Wang,1 Robert T Chang21Stanford University, Stanford, CA, USA; 2Stanford University School of Medicine, Stanford, CA, USAAbstract: Rho kinase (ROCK) inhibitors are a novel potential class of glaucoma therapeutics with multiple compounds currently ...
Wang SK, Chang RT
doaj  

Genome-wide RNA-Sequencing analysis reveals a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery [PDF]

, 2017
Fibrosis-related events play a part in most blinding diseases worldwide. However, little is known about the mechanisms driving this complex multifactorial disease.
A Dobin, A Joannes, A Mahale, A Mortazavi, A Sokolović, AC Lake, AJ Haak, B Eyden, B Hinz, B Hinz, BA Mast, BL Riser, C Esnault, C Yu-Wai-Man, C Yu-Wai-Man, CA Fielding, D Bergamaschi, D Broadway, DW Esson, EM Addicks, EN Olson, G Bindea, H Guo, H Li, H Li, H Tao, HP Lorenz, HR Mason, IH Oh, J Ji, J Wang, J Yang, JC Bleacher, JJ Brown, JM Matthews, JS Stumhofer, K Akino, K Alitalo, K Seki, KA Frewer, KL Du, KW Liechty, L Li, M Aoyama, M Sabbah, MI Love, MP Popp, MR Namazi, N Erez, P Shannon, PG Pelicci, PO Yoon, R Gaujoux, S Anders, S Banerjee, S Kim, T Imai, T Luedde, T Minami, T Nakamura, TA Wynn, TH Sisson, TT Le, X Zhang, Y Benjamini, Y Drabsch, Y Su, Z Wang, Z Wang   +68 more
core   +2 more sources

Peripheral vestibular syndrome in cats: Clinical presentation, diagnostic findings and outcome in 196 cases

Veterinary Record, EarlyView.
Abstract Background Disorders of the vestibular system are frequent in cats. This study aimed to describe the clinical presentation, diagnostic findings, underlying aetiologies and outcome of cats with peripheral vestibular syndrome (PVS). Methods This was a retrospective study of cats presented with PVS at four referral hospitals.
Jordina Caldero Carrete, Steven De Decker, Holger A. Volk, Rodrigo Gutierrez‐Quintana, Anna Morgana Mosel, Rita Gonçalves   +5 more
wiley   +1 more source

Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle [PDF]

, 2017
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable ...
Hurley, Tanner, Klausner, Adam P., Lin, Jia B., Miner, Amy S., Neal, Christopher J., Ratz, Paul H., Speich, John E.   +6 more
core   +2 more sources

Iatrogenic pulsus alternans in a dog undergoing median sternotomy

Veterinary Record Case Reports, EarlyView.
Abstract A 6‐year‐old, 21.8 kg, female, spayed Siberian husky was referred for management of a spontaneous bilateral pneumothorax, due to a ruptured pulmonary bleb. During surgery, sterile saline was instilled on three occasions in order to locate the damaged lung tissue and ensure complete ligation.
Marie‐Line Doï, Alexandra R. Robinson, Jill K. Maney   +2 more
wiley   +1 more source

Pericardium of the frog, Rana esculenta, is morphologically designed as a lymphatic space [PDF]

, 2003
The importance of the pericardium and the pericardial fluid (PF) in the control of cardiac function has emerged over the past few years. Despite the acknowledgment that amphibians are exposed to both dehydration and excessive water accumulation, nothing ...
Amelio, D., Cerra, M., FARINA, Felicia, MARCIANO', Vito, PALMA, Antonio, Tavolaro, P.   +5 more
core   +2 more sources

Assessment of endoscopic and external approaches for frontal sinus lesions

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Objectives The use of endoscopic approaches has revolutionized the management of frontal sinus (FS) lesions. However, external approaches still play a significant role in select conditions. Various factors determine the decision to utilize endoscopic or external approaches such as the lesion location, extension, and patient's characteristics ...
Moataz D. Abouammo, Hossam S. Elsherif, Medhat M. H. Mansour, Magdy E. Saafan, Ricardo L. Carrau, Mahmoud F. Abdelaziz   +5 more
wiley   +1 more source

Fuchs Heterochromic Iridocyclitis-Associated Glaucoma: A Retrospective Comparison of Primary Ahmed Glaucoma Valve implantation and Trabeculectomy with MMC [PDF]

, 2017
Purpose: To compare the safety and efficacy of a primary trabeculectomy with mitomycin C (T) and an Ahmed glaucoma valve (AGV) implantation in patients with Fuchs heterochromic iridocyclitis (FHIC) related glaucoma, a rare complication of an uncommon ...
Esfandiari, Hamed, Fatourechi, A, Hassanpour, Kiana, Loewen, Nils A., Pakravan, Mohammad, Yaseri, M, Yazdani, S   +6 more
core  

Fixation-induced cell blebbing on spread cells inversely correlates with phosphatidylinositol 4,5-bisphosphate level in the plasma membrane [PDF]

, 2014
While most attention has been focused on physiologically generated blebs, the molecular mechanisms for fixation-induced cell blebbing are less investigated. We show that protein-fixing (e.g. aldehydes and picric acid) but not lipid-stabilizing (e.g. OsO4
Ao, Meiying, Chen, Yong, Liao, Huanhuan, Wu, Li, Zhang, Xiaojun, Zhao, Siyuan   +5 more
core   +2 more sources