Results 41 to 50 of about 905,182 (316)

Is The Co-administration of Metformin and Clomiphene Superior to Induce Ovulation in Infertile Patients with Poly Cystic Ovary Syndrome and Confirmed Insulin-resistance: A Double Blind Randomized Clinical Trial

Journal of Family and Reproductive Health, 2023
Objective: This study aimed to compare the effects of clomiphene citrate (CC) combined with metformin or placebo on infertile patients with poly cystic ovary syndrome (PCOS) and insulin resistance (IR).
Azam Azargoon, Human Mousavi Fatemi, Majid Mirmohammadkhani, Satinik Darzi   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

PHARMACOKINETIC-GUIDED PROPHYLAXIS FOR PEOPLE WITH HEMOPHILIA A

Hematology, Transfusion and Cell Therapy, 2021
Pharmacokinetic (PK)-guided prophylaxis for people with hemophilia A (PwHA) treatment has been related to fewer bleeding and cost savings have been reported.
ACO Borges, PC Giacometto, L Hirle, TH Anegawa, MK Amarante, J Álvares-Teodoro, LL Jardim, RM Camelo   +7 more
doaj   +1 more source

To Bleed‐Off or Not to Bleed‐Off?

Geophysical Research Letters
Abstract Bleed‐off and shut‐in of injection have been implemented in different Enhanced Geothermal Systems (EGS) in an attempt to mitigate the induced seismicity at and after the injection stop. This article tackles the controversial discussion on the mitigation of the post‐injection induced seismicity through ending fluid injection ...
Boyet, Auregan, De Simone, Silvia, Vilarrasa, Víctor   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Knowledge and therapeutic gaps : a public health problem in the rare coagulation disorders population

, 2011
Rare coagulation disorders (RCDs) present a considerable and multifaceted public health risk. Although inherited RCDs affect a minor segment of any local healthcare delivery system, their global impact is major and highlight the challenges of delivering ...
J. M. Soucie, Clotting Disorders Working Group, UDC Rare Bleeding, D. M. Dimichele, the European Network Rare Bleeding Disorders Database, A. D. Shapiro, D. J. Aschman, F. Peyvandi   +7 more
core   +1 more source

Prediction of in-hospital bleeding in acutely ill medical patients: External validation of the IMPROVE bleeding risk score [PDF]

, 2023
INTRODUCTION Pharmacological thromboprophylaxis slightly increases bleeding risk. The only risk assessment model to predict bleeding in medical inpatients, the IMPROVE bleeding risk score, has never been validated using prospectively collected outcome
Christine Baumgartner, Pauline Darbellay Farhoumand, Tobias Tritschler, Drahomir Aujesky, Aujesky, Drahomir, Rossel, Jean-Benoît, Marie Méan, Tritschler, Tobias, Darbellay Farhoumand, Pauline, Choffat, D., Rossel, J.B., Juillard, Pauline, Pauline Julliard, Baumgartner, Christine, Aujesky, D., Darbellay Farhoumand, P., Stalder, O., Stalder, Odile, Villiger, R., Villiger, Rahel, Odile Stalder, Choffat, Damien, Méan, M., Damien Choffat, Méan, Marie, Jean-Benoît Rossel, Julliard, P., Tritschler, T., Baumgartner, C., Rahel Villiger   +29 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Self-Reporting Questionnaire on Gingival Bleeding Among Dental Students at University of Sulaimani [PDF]

, 2017
Objective: Gingival bleeding during tooth brushing and eating is a clinical sign of gingivitis and periodontitis, or infrequentlydue to some associated systemic conditions or diseases such as vitamin C deficiency and blood diseases.
Dler A. Khursheed, Faraedun M. Zardawi, Shamal S. Zorab, Sarhang S. Gul   +3 more
core   +1 more source