Results 41 to 50 of about 1,063,323 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Drug interactions and risk of acute bleeding leading to hospitalisation or death in patients with chronic atrial fibrillation treated with warfarin [PDF]

, 2005
Summary: Although drug interactions with warfarin are an important cause of excessive anticoagulation, their impact on the risk of serious bleeding is unknown.We therefore performed a cohort study and a nested case-control analysis to determine the ...
Meier, Christoph R., Haefeli, Walter E., Hollowell, Jennifer., Gasse, Christiane.   +3 more
core  

Bleeding-related adverse events with an incidence >1% in patients undergoing any type of surgery.

, 2018
Bleeding-related adverse events with an incidence >1% in patients undergoing any type of surgery.
Yoshihiro Ogawa (15560), Takuhiro Yamaguchi (561419), Yasuhiro Miyauchi (5828873), Masatada Hirata (5828879), Kazutoshi Izawa (5828876), Masakazu Tanaka (493432), Yasunari Sadatsuki (5828882), Yukio Kitajima (5828870)   +7 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Evaluation of Patients with Post-Tonsillectomy Bleeding in a Second-Degree State Hospital Our Patients with Post-Tonsillectomy Bleeding

, 2014
Aim: Investigation of features of patients with post-tonsillectomy bleeding and evaluation of clinical approach to those patients in a second-degree state hospital.
Mustafa Suphi Elbistanlı, Tolgar Lütfi Kumral, Şebnem Elbistanlı, Reşit Murat Açıkalın   +3 more
core   +1 more source

Platelet count and risk of major bleeding in venous thromboembolism [PDF]

, 2020
The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear.
Brækkan, Sigrid Kufaas, Vânia M. Morelli, Morelli, Vania Maris, Johnsen, Håkon Sandbukt, Hansen, John-Bjarne, Sandbukt Johnsen, Håkon, John-Bjarne Hansen, Sigrid K. Braekkan, Håkon S. Johnsen   +8 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Assessment of Bleeding Risks and Patient Knowledge Levels About Bleeding Disorders in Patients Referred to the Oral and Maxillofacial Surgery Clinic [PDF]

Objective: The objective of this study was to examine patients’ awareness of bleeding disorders in dental clinics and to identify patients with bleeding disorders using the International Society on Thrombosis and Haemostasis-Bleeding Assessment Tools ...
Kaya, ZÜHRE, Nur Mollaoğlu, Öztürk Gündoğdu, Öykü, Zühre Kaya, Mollaoğlu, Nur, Çankal, Dilek Aynur, Öykü Öztürk Gündoğdu, Çege, Muhammed Abdullah, Dilek Aynur Çankal, Abdullah Çege   +9 more
core   +1 more source