Results 171 to 180 of about 127,419 (262)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause. [PDF]

Res Pract Thromb Haemost
Dreier T, Mehic D, Oosterlee J, Rast J, Kaider A, Haslacher H, Ay C, Pabinger I, Gebhart J.   +8 more
europepmc   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Correction to "Reference Values for the Haemophilia Joint Health Score in Patients With Severe Haemophilia Derived From the Canadian Bleeding Disorder Registry". [PDF]

Haemophilia
europepmc   +1 more source

How to treat patients with bleeding disorder of unknown cause? [PDF]

Res Pract Thromb Haemost
Mussert C, Monard A, Heubel-Moenen F.
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Screening Yield of Inherited Bleeding Disorder Questionnaires in Women With Chronic Heavy Menstrual Bleeding (HMB): A Cross-Sectional Study. [PDF]

Cureus
Faiz A, Dawelbait Radwan ME, Iqbal S, Vinayak S, Gowda D, Mani Tripathi K, Mahmood GM, Akbar H, Kanwal M, Sunil A, Al Niazi R, Naeem A.   +11 more
europepmc   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Mild or moderate hemophilia is not always a mild or moderate bleeding disorder: Back to the clinical phenotype. [PDF]

Hemasphere
Rodeghiero F, Ghiotto L, Pontalto L, Casini A, Castaman G, Abdul-Kadir R, Berntorp E, Bodó I, Degenaar-Dujardin M, Fijnvandraat K, Gresele P, Key NS, Lassila R, Leebeek FWG, Lillicrap D, Makris M, Meijer S, Mezzano D, Noris P, Pabinger I, Ragni MV, Silva D, Srivastava A, Tosetto A, Windyga J, Zieger B.   +25 more
europepmc   +1 more source