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Genetics in Medicine, 2011 von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral cavity bleeding, menorrhagia, bleeding after dental extraction, surgery, and/or childbirth, and in severe cases, bleeding into joints and soft tissues.
Anne Goodeve +2 more
exaly +3 more sources
BMC Anesthesiology, 2019 Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
H.-G. Topf +5 more
doaj +2 more sources
Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
Haematologica, 2019 Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction.
Loredana Bury +5 more
doaj +2 more sources
Haematologica, 2017 Molecular diagnosis of patients with von Willebrand disease is pending in most populations due to the complexity and high cost of conventional molecular analyses.
Nina Borràs +48 more
doaj +2 more sources
Von Willebrand disease mutation spectrum and associated mutation mechanisms.
Thrombosis Research, 2017 A. de Jong, J. Eikenboom
semanticscholar +3 more sources
ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease.
Blood Advances, 2021 BACKGROUND von Willebrand disease (VWD) is the most common inherited bleeding disorder known in humans. Accurate and timely diagnosis presents numerous challenges.
P. James +18 more
semanticscholar +1 more source
ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease.
Blood Advances, 2021 BACKGROUND von Willebrand disease (VWD) is a common inherited bleeding disorder. Significant variability exists in management options offered to patients.
Nathan T Connell +18 more
semanticscholar +1 more source
Blood, 2022 International guidelines suggest long-term prophylaxis in patients with von Willebrand disease (VWD) and recurrent severe or frequent bleeds. Leebeek and colleagues report on the results of a nonrandomized trial of recombinant von Willebrand factor (rVWF)
F. Leebeek +11 more
semanticscholar +1 more source
Von Willebrand Disease: Current Status of Diagnosis and Management
Hematology/Oncology Clinics of North America, 2021 Von Willebrand disease (VWD) is a common bleeding disorder, affecting male and female individuals equally, that often manifests in mucosal bleeding.
A. Weyand, Veronica H. Flood
semanticscholar +1 more source