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Von Willebrand disease: A century of progress [PDF]

Research and Practice in Thrombosis and Haemostasis
One hundred years after the initial description of von Willebrand disease, originally referred to as pseudohemophilia, this article is a tribute to Dr Erik von Willebrand and a testament to the progress in our understanding of von Willebrand factor. Main
Caterina Casari, Brooke Sadler, Sophie Susen, Riitta Lassila   +3 more
doaj   +2 more sources

VON WILLEBRAND DISEASE [PDF]

Romanian Journal of Pediatrics, 2009
Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a defi cit in the ...
Valeriu Popescu, Andrei Zamfirescu
doaj   +3 more sources

Undiagnosed von Willebrand Disease Presenting as Delayed Hematoma after Total Hip Arthroplasty: A Case Report [PDF]

Journal of Orthopaedic Case Reports
Introduction: Total hip arthroplasty is an effective procedure for end-stage hip disease, yet post-operative hematoma may signal an underlying bleeding disorder, particularly when the presentation is delayed.
Derick Rodríguez-Reyes, Hiram E Luigi-Martínez, Joseph Salem-Hernández, Francis Robles-Torres, Lorenzo Acevedo, Rafael Fernández-Soltero   +5 more
doaj   +2 more sources

Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]

Journal of Medical Biochemistry, 2021
Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika, Szanto Timea, Viigimaa Margus, Lejniece Sandra, Balode Dārta, Saks Kadri, Banys Valdas   +6 more
doaj   +1 more source

von Willebrand factor activity and activated partial thromboplastin time as proxy biomarkers for coagulopathies in women with menorrhagia in Zambia: a case-control study

The Pan African Medical Journal, 2021
INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje, Trevor Kaile, Sumbukeni Kowa, Musalula Sinkala, Marah Simakando, Jacob Ndhlovu, Brian Chanda Chiluba   +6 more
doaj   +1 more source

Cryptic non-canonical splice site activation is part of the mechanism that abolishes multimer organization in the c.2269_2270del von Willebrand factor

Haematologica, 2020
We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone, Eva Galletta, Luigi De Marco, Alessandra Casonato   +3 more
doaj   +1 more source

An apparently silent nucleotide substitution (c.7056C>T) in the von Willebrand factor gene is responsible for type 1 von Willebrand disease

Haematologica, 2011
Background Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases.Design and Methods We report an altered splicing process induced by a silent
Viviana Daidone, Lisa Gallinaro, Maria Grazia Cattini, Elena Pontara, Antonella Bertomoro, Antonio Pagnan, Alessandra Casonato   +6 more
doaj   +1 more source

Principles of care for the diagnosis and treatment of von Willebrand disease

Haematologica, 2013
Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in ...
Giancarlo Castaman, Anne Goodeve, Jeroen Eikenboom   +2 more
doaj   +1 more source

Pregnancy and delivery in women with von Willebrand’s disease and different von Willebrand factor mutations

Haematologica, 2010
Background Pregnancy in von Willebrand’s disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty.Design ...
Giancarlo Castaman, Alberto Tosetto, Francesco Rodeghiero   +2 more
doaj   +1 more source

A thrombopoietin receptor agonist to rescue an unusual platelet transfusion-induced reaction in a p.V1316M-associated von Willebrand disease type 2B patient

Therapeutic Advances in Hematology, 2022
This report describes the first case of splenic injury in a patient with p.V1316M-associated von Willebrand disease type 2B (VWD2B) with chronic thrombocytopenia, successfully treated with nonoperative management including von Willebrand factor (VWF ...
Caterina Casari, Remi Favier, Paulette Legendre, Alexandre Kauskot, Frederic Adam, Veronique Picard, Peter J. Lenting, Cecile V. Denis, Valerie Proulle   +8 more
doaj   +1 more source