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Diagnosis of von Willebrand disease [PDF]
Blood Advances: von Willebrand disease (VWD) is the most common inherited bleeding disorder, resulting from a deficiency and/or dysfunction of von Willebrand factor (VWF).
Mackenzie Bowman, Paula James
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Individualizing dosing frequency may improve the efficacy of prophylaxis in patients with von Willebrand disease—a WIL-31 subanalysis [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: The efficacy and safety of prophylaxis with wilate, a plasma-derived von Willebrand factor/factor VIII concentrate, was demonstrated in patients with von Willebrand disease of all types in the WIL-31 study.
Robert F. Sidonio, Jr. +5 more
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Evaluation of a new semi-automated Hydragel 11 von Willebrand factor multimers assay kit for routine use [PDF]
Journal of Medical Biochemistry, 2021 Background: Accurate diagnosis and classification of von Willebrand disease (VWD) are essential for optimal management. The von Willebrand factor multimers analysis (VWF:MM) is an integral part of the diagnostic process in the phenotypic classification ...
Pikta Marika +6 more
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Romanian Journal of Pediatrics, 2009 Described by Erik Adolf von Willebrand in 1926, it is a constitutional hemorrhagic disease, inherited in the autosomal mode. Considered initially as a thrombopathic disease, then as a prologation of the bleeding time associated to a defi cit in the ...
Valeriu Popescu, Andrei Zamfirescu
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The Pan African Medical Journal, 2021 INTRODUCTION: von Willebrand Disease (vWD) is the most prevalent bleeding disorder. Women are more likely to manifest abnormal bleeding symptoms due to physiologic events and menorrhagia is the most common presenting symptom.
Miyoba Melinda Munsanje +6 more
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Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses [PDF]
, 2013 <p>Background: Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand ...
Aspelund, T. +7 more
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Haematologica, 2020 We report a new pathogenic mechanism in von Willebrand disease involving the use of a non-canonical splicing site. The proband, carrying the homozygous c.2269_2270del mutation previously classified as a type 3 mutation, showed severely reduced plasma and
Viviana Daidone +3 more
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, 2017 Von Willebrand Disease (VWD) is a blood clotting disorder characterized by low levels of the Von Willebrand Factor (VWF) in the blood. VWF is functions to bind platelets and promote clotting of the blood when vascular injury occurs.
Misla David, Ramon
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Haematologica, 2011 Background Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases.Design and Methods We report an altered splicing process induced by a silent
Viviana Daidone +6 more
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Diagnosis of von Willebrand disease in Argentina: a single institution experience [PDF]
, 2017 von Willebrand disease (VWD) is the most common autosomal bleeding disorder, mostlyinherited as dominant trait. VWD is due to deficiency/abnormality of von Willebrand factor (VWF).
Blanco, Alicia Noemi +5 more
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