Results 11 to 20 of about 44,755 (204)

The Molecular Genetics of von Willebrand Disease

Turkish Journal of Hematology, 2012
Quantitative and/or qualitative deficiency of von Willebrand factor (vWF) is associated with the most common inherited bleeding disease von Willebrand disease (vWD). vWD is a complex disease with clinical and genetic heterogeneity.
Ergül Berber
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Spontaneous iliopsoas muscle hematoma in a patient with von Willebrand disease: a case report

Journal of Medical Case Reports, 2011
Introduction Iliopsoas hemorrhage is a serious complication of bleeding disorders that occurs most commonly in patients with hemophilia and less commonly in patients with von Willebrand disease.
Soltani Shirazi Ahmad, Keikhaei Bijan
doaj   +2 more sources

Mechanisms of thrombocytopenia in platelet-type von Willebrand disease [PDF]

Haematologica, 2019
Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction.
Loredana Bury, Alessandro Malara, Stefania Momi, Eleonora Petito, Alessandra Balduini, Paolo Gresele   +5 more
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Treatment of Von Willebrand Disease [PDF]

Thrombosis and Haemostasis, 1998
SummaryIn von Willebrand disease, there are two main options for the treatment of spontaneous bleeding episodes and for bleeding prophylaxis: desmopressin and transfusional therapy with plasma products. Desmopressin is the treatment of choice for most patients with type 1, who account for approximately 70 to 80 per cent of all cases with the disease ...
C. A. Lee, C. M. Kessler, D. Varon, U. Martinowitz, M. Heim, P. M. MANNUCCI   +5 more
openaire   +7 more sources

Von Willebrand Disease in the elderly: clinical perspectives

Clinical Interventions in Aging, 2018
John Chapin Department of Hematology, Shire, Lexington, MA, USA Abstract: Von Willebrand disease (VWD) is an inherited bleeding disorder that affects up to 1% of the population. In most cases, VWD results from a mutation in the von Willebrand Factor (VWF)
Chapin J
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Pseudo (Platelet-type) von Willebrand disease in pregnancy: a case report

BMC Pregnancy and Childbirth, 2013
Background Pseudo (platelet-type)-von Willebrand disease is a rare autosomal dominant bleeding disorder caused by an abnormal function of the glycoprotein lb protein; the receptor for von Willebrand factor.
Grover Neetu, Boama Vincent, Chou Munazzah Rifat   +2 more
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A thrombopoietin receptor agonist to rescue an unusual platelet transfusion-induced reaction in a p.V1316M-associated von Willebrand disease type 2B patient

Therapeutic Advances in Hematology, 2022
This report describes the first case of splenic injury in a patient with p.V1316M-associated von Willebrand disease type 2B (VWD2B) with chronic thrombocytopenia, successfully treated with nonoperative management including von Willebrand factor (VWF ...
Caterina Casari, Remi Favier, Paulette Legendre, Alexandre Kauskot, Frederic Adam, Veronique Picard, Peter J. Lenting, Cecile V. Denis, Valerie Proulle   +8 more
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Pregnancy and delivery in women with von Willebrand’s disease and different von Willebrand factor mutations

Haematologica, 2010
Background Pregnancy in von Willebrand’s disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty.Design ...
Giancarlo Castaman, Alberto Tosetto, Francesco Rodeghiero   +2 more
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Insights into pathological mechanisms of missense mutations in C-terminal domains of von Willebrand factor causing qualitative or quantitative von Willebrand disease

Haematologica, 2013
The carboxyl-terminal domains of von Willebrand factor, D4-CK, are cysteine-rich implying that they are structurally important. In this study we characterized the impact of five cysteine missense mutations residing in D4-CK domains on the conformation ...
Hamideh Yadegari, Julia Driesen, Anna Pavlova, Arijit Biswas, Vytautas Ivaskevicius, Robert Klamroth, Johannes Oldenburg   +6 more
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Fifth Åland Island conference on von Willebrand disease [PDF]

, 2018
The fifth Åland Island meeting on von Willebrand disease (VWD) was held on the Åland Islands, Finland, from 22 to 24 September 2016 – 90 years after the first case of VWD was diagnosed in a patient from the Åland Islands in 1926.
Windyga, J, Goudemand, J, Aledort, L., Mourik, M, T. Szántó, Blombäck, M., Cnossen, M H, Mannucci, PM, Berntorp, E., Goudemand J., Berntorp, E, von Depka M., E. Berntorp, Federici, A.B., J. Goudemand, Ågren, A, Onundarson P. T., Aledort L., Szanto T., Berntorp E., Mourik M., Mannucci, P. M., Goodeve, A, Windyga, J., Önundarson, P. T., Mannucci, P M, J. Windyga, Croteau, S.E., Onundarson, PT, Federici A. B., Aledort, L, M. von Depka, P. T. Önundarson, S. E. Croteau, Mannucci, P.M., Rodeghiero, F., A. B. Federici, M. Mourik, Croteau, SE, F. Rodeghiero, Goodeve A., Önundarson, P.T., Croteau, S E, Blomback M., Mannucci P. M., Ågren, A., Cnossen, M. H., M. H. Cnossen, Agren A., Rodeghiero F., A. Goodeve, von Depka, M, M. Blombäck, Goodeve, A., Croteau, S. E., Cnossen M. H., Szántó, T., Rodeghiero, F, A. Ågren, Goudemand, J., Federici, A. B., Cnossen, M.H., P. M. Mannucci, Cnossen, Marjon, Federici, A B, Szántó, T, Mourik, M., Federici, AB, Windyga J., von Depka, M., Blombäck, M, L. Aledort, Croteau S. E., Önundarson, P T   +73 more
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