Results 261 to 270 of about 611,543 (320)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Sequential Application of Autologous Platelet Rich Plasma and Muscle-Derived Mesenchymal Stem Cells for Acute Tendon Injuries in Horses: Early Clinical and Ultrasonographic Outcomes in a Randomized, Double-Blind Controlled Study. [PDF]

Animals (Basel)
Serteyn D, Graide H, Ceusters J, Vandersmissen M, Salciccia A, Sandersen C, Lejeune JP.   +6 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Education, work, and the production of vulnerability: experiences of women with visual impairments in China. [PDF]

Front Sociol
Chen M.
europepmc   +1 more source

Open-set blind recognition of non-binary LDPC codes

Ming Jiang, Dongrui Huan, Shiqiu Liu, Junhui Zhao   +3 more
openalex   +1 more source

Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice. [PDF]

Sci Rep
Lizarraga-Valderrama LR, Williams S, Watson DJG, Granger KT, Gibson CL, Moran PM.   +5 more
europepmc   +1 more source

Sensitivity to Geometric Shape Regularity Emerges Independently of Vision. [PDF]

Open Mind (Camb)
Adriano A, Sablé-Meyer M, Ciccione L, Zhan M, Dehaene S.   +4 more
europepmc   +1 more source

Emergency critical care: a blind spot in the upstream phase of critical illness. [PDF]

Crit Care
Kümpers P, Rovas A, Köhnke R, Pinkernell L, Reindl M, Michael M, Bernhard M.   +6 more
europepmc   +1 more source

Hypovolemic phlebotomy and low central venous pressure: a paradigm shift in liver surgery? [PDF]

Hepatobiliary Surg Nutr
Eyraud D, Cordeiro A.
europepmc   +1 more source