Results 231 to 240 of about 2,900,353 (313)

Information bubble and skill evolution: a theoretical framework for integrating distributed cognition, cognition offloading, and metacognitive regulation based on AIOE. [PDF]

Front Artif Intell
Lu T, Cheng Z.
europepmc   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Between map and maze: reframing trust in healthcare AI. [PDF]

AI Soc
Piehl HS, Janssen R, Penders B, Fijten RRR.   +3 more
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Whole cell inactivated poly-bacterial preparation MV130 effect on nasal mucosal immunity and experimental human pneumococcal carriage: double-blind randomised controlled trial with controlled human infection model. [PDF]

EBioMedicine
Ndaferankhande J, Jambo KC, Chikaonda T, Tembo G, Conejero L, Henrion MYR, Kudowa E, Lipunga G, Chirwa AE, Nsomba E, Mayuni MC, Mailboy M, Sigoloti A, Dzonzi B, Mangani E, Nkhoma V, Songolo S, Toto N, Thole F, Banda NPK, Galafa B, Kadzanja G, Kamanga MP, Chimgoneko L, Nthandira T, Tembo BM, Muyaya A, Makhaza L, Lipenga B, Katangwe V, Chiwala G, Grigg J, Gordon SB, MARVELS consortium.   +33 more
europepmc   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Effectiveness of intensive community care services for adolescents with acute psychiatric emergencies: findings from a feasibility multi-centre, parallel-group, single-blinded RCT.

Health Technol Assess
Ougrin D, Thaventhiran T, Wong B, Pilecka I, Landau S, Byford S, Chu P, Heslin M, Tassie E, Reavey P, Atanda OO, Mehdi T, Wait M, Zundel T, Tolmac J, Clacey J, Wehncke L, Dobler V, Baker E, Collier J, Bevan-Jones R, Jafari H, Woolhouse R.   +22 more
europepmc   +1 more source

Exploring Trust Black-Swan Blindness in Social Internet of Vehicles (SIoV)

Proceedings of the 12th ACM/IEEE International Workshop on Software Engineering for Systems-of-Systems and Software Ecosystems
Hind Bangui, Barbora Buhnova, Dasa Kusniráková   +2 more
openaire   +2 more sources

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Sentient AI in robots and agents: prolegomena for an evidence-based research program. [PDF]

Front Psychol
Chella A.
europepmc   +1 more source