Results 61 to 70 of about 455,319 (289)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Myopia prevalence, refractive status and uncorrected myopia among primary and secondary school students in Germany

Frontiers in Medicine
IntroductionThe increasing prevalence of myopia worldwide is problematic because myopia can result in severe secondary pathologies, and is associated with considerable financial burden.
Astrid Hönekopp, Lisa-Marie Tommes, Philipp Doebler, Sarah Weigelt   +3 more
doaj   +1 more source

KR-31378, a Potassium-Channel Opener, Induces the Protection of Retinal Ganglion Cells in Rat Retinal Ischemic Models

Journal of Pharmacological Sciences, 2009
KR-31378 is a newly developed KATP-channel opener. To investigate the ability of KR-31378 to protect retinal ganglion cells (RGC), experiments were conducted using two retinal ischemia models.
Anho Choi, Jun-Sub Choi, Yone-Jung Yoon, Kyung-A Kim, Choun-Ki Joo   +4 more
doaj   +1 more source

Faces do not capture special attention in children with autism spectrum disorder: a change blindness study [PDF]

, 2009
Two experiments investigated attention of children with autism spectrum disorder (ASD) to faces and objects. In both experiments, children (7- to 15-year-olds) detected the difference between 2 visual scenes.
Adolphs, American Psychiatric Association, Aylward, Baron-Cohen, Bird, Critchley, Dalton, Dawson, Dawson, Farroni, Fletcher-Watson, Grelotti, Hadjikhani, Hadjikhani, Happé, Haxby, Hobson, Howard, Hubl, Humphreys, Japanese WISC-III Publication Committee, Johnson, Johnson, Joseph, Kemper, Klin, Klin, Langton, Levin, Maestro, Mars, Matsumoto, Morton, Osterling, Osterling, O’Regan, Palermo, Pierce, Piggot, Raven, Rensink, Rensink, Ro, Ro, Scholl, Schultz, Schultz, Schumann, Shah, Shore, Sigman, Simons, Simons, Simons, Sparks, Speer, Spezio, Sugishita, Swettenham, van der Geest, Vuilleumier, Wang, Wechsler, Werner, Wimpory, Wojciulik, Yokosawa   +66 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A Hospital Based Study Regarding Awareness of Association Between Glycosylated Haemoglobin and Severity of Diabetic Retinopathy in Type 2 Diabetic Individuals [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Diabetic retinopathy is one of the most common microvascular complications seen in diabetic patients after a long term of uncontrolled glycaemic status as assessed by glycosylated Haemoglobin A (HbA1c).
Mridula Prabhu, Anupama Kakhandaki, K.R. Pravin Chandra, M.B. Dinesh   +3 more
doaj   +1 more source

Merleau-Ponty, World-Creating Blindness, and the Phenomenology of Non-Normate Bodies [PDF]

, 2017
An increasing number of scholars at the intersection of feminist philosophy and critical disability studies have turned to Merleau-Ponty to develop phenomenologies of disability or of what, following Rosemarie Garland-Thomson, I call "non-normate ...
Reynolds, Joel Michael
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Thin-layer chromatography of hydroxamic acids

Journal of Lipid Research, 1967
The separation of very short-chain from longchain fatty acyl hydroxamates by thin-layer chromatography is described. The detection limit was 2 μg.
Eberhardg G. Trams
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source