Results 71 to 80 of about 249,251 (264)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Interleaver Design for Parallel Concatenated Block Codes With Arbitrary Lengths

IEEE Access
Parallel Concatenated Block (PCB) codes are conventionally constituted by two identical linear systematic block codes, as component codes, linked by an interleaver. In general, the PCB code’s interleaver length (or message length) is the square of
Vijayasri Sundarapuram Soundayan, Sina Vafi   +1 more
doaj   +1 more source

Blocking sets, minimal codes and trifferent codes

Journal of the London Mathematical Society
AbstractWe prove new upper bounds on the smallest size of affine blocking sets, that is, sets of points in a finite affine space that intersect every affine subspace of a fixed codimension. We show an equivalence between affine blocking sets with respect to codimension‐2 subspaces that are generated by taking a union of lines through the origin, and ...
Anurag Bishnoi, Jozefien D'haeseleer, Dion Gijswijt, Aditya Potukuchi   +3 more
openaire   +4 more sources

On the Many Faces of Block Codes

, 2000
Block codes are first viewed as finite state automata represented as trellises. A technique termed subtrellis overlaying is introduced with the object of reducing decoder complexity. Necessary and sufficient conditions for subtrellis overlaying are next derived from the representation of the block code as a group, partitioned into a subgroup and its ...
DESHMUKH, K, SHANKAR, P, DASGUPTA, A, RAJAN, BS   +3 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Industrial Metaverse and Technical Diagnosis of Electric Drive Systems

Applied Sciences
This article presents a part of the industrial metaverse for electric drive system diagnostics. The advantages of using a low-code/no-code platform for electric drive systems diagnostics are demonstrated.
Natalia Koteleva, Nikolay Korolev, Margarita Kovalchuk   +2 more
doaj   +1 more source

Minimum BER Receiver Filters with Block Memory for Uplink DS-CDMA Systems

EURASIP Journal on Wireless Communications and Networking, 2008
The problem of synchronous multiuser receiver design in the case of direct-sequence single-antenna code division multiple access (DS-CDMA) uplink networks is studied over frequency selective fading channels.
Mérouane Debbah, Are Hjørungnes   +1 more
doaj   +1 more source