Results 131 to 140 of about 5,909,835 (371)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The maximum residual block Kaczmarz algorithm based on feature selection

open access: yesAIMS Mathematics
Based on the K-means method, an effective block-row partitions algorithm was proposed in [1], which involves partitioning the rows of the coefficient matrix $ A \in {\mathbb{R}^ {m \times n}} $.
Ran-Ran Li, Hao Liu
doaj   +1 more source

基于块分裂求解线性互补问题的新模系同步多分裂方法(New modulus-based synchronous multisplitting methods based on block splitting for linear complementarity problems)

open access: yesZhejiang Daxue xuebao. Lixue ban, 2018
Based on the existing algorithms,we further study relaxed modulus-based synchronous block multisplitting multi-parameters methods for linear complementarity problem. Furthermore, we give the weaker convergence results of our new method in this paper when
ZHANGLitao(张理涛)   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study of matrix micro-cracking in nano clay and acrylic tri-block-copolymer modified epoxy/basalt fiber-reinforced pressure-retaining structures

open access: yeseXPRESS Polymer Letters, 2011
In fiber-reinforced polymer pressure-retaining structures, such as pipes and vessels, micro-level failure commonly causes fluid permeation due to matrix cracking.
doaj   +1 more source

Block covariance matrix estimation with structured off-diagonal blocks

open access: yesStatistical Papers
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Monika Mokrzycka, Malwina Mrowińska
openaire   +2 more sources

Home - About - Disclaimer - Privacy