Results 71 to 80 of about 1,500,614 (287)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Roots of Characteristic Polynomial Sequences in Iterative Block Cyclic Reductions

Mathematics, 2021
The block cyclic reduction method is a finite-step direct method used for solving linear systems with block tridiagonal coefficient matrices. It iteratively uses transformations to reduce the number of non-zero blocks in coefficient matrices.
Masato Shinjo, Tan Wang, Masashi Iwasaki, Yoshimasa Nakamura   +3 more
doaj   +1 more source

Fast Hessenberg reduction of some rank structured matrices

, 2016
We develop two fast algorithms for Hessenberg reduction of a structured matrix $A = D + UV^H$ where $D$ is a real or unitary $n \times n$ diagonal matrix and $U, V \in\mathbb{C}^{n \times k}$.
Gemignani, Luca, Robol, Leonardo
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

ACCURACY ESTIMATION OF METHOD FOR PARAMETERS MEASUREMENT OF PULSE SIGNALS AND OFDM (N-OFDM) SIGNALS

Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2018
For the first time, with the help of mathematical modelling, clarified the properties of the received analytical relations and set the limits possibilities of OFDM (N-OFDM) signal demodulation method in the background of impulse signals in the integrated
Vadym I. Slusar, Andrii O. Zinchenko, Yurii H. Danyk   +2 more
doaj  

The Block Landweber Iterative Method for Light Field Reconstruction from a Focal Stack

Photonics, 2023
Light field imaging involves reconstructing a 4D light field from a 3D focal stack, which makes it challenging to reconstruct the light field from incomplete projection data. To address this problem, a linear projection system is established to model the
Yuhan Liu, Gangrong Qu, Shan Gao
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Towards finding equalities involving mixed products of the Moore-Penrose and group inverses by matrix rank methodology

Demonstratio Mathematica
Given a square matrix AA, we are able to construct numerous equalities involving reasonable mixed operations of AA and its conjugate transpose A∗{A}^{\ast }, Moore-Penrose inverse A†{A}^{\dagger } and group inverse A#{A}^{\#}. Such kind of equalities can
Tian Yongge
doaj   +1 more source