Results 71 to 80 of about 2,984,671 (302)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A fast algorithm for matrix balancing [PDF]
, 2013 As long as a square nonnegative matrix A contains sufficient nonzero elements, then the matrix can be balanced, that is we can find a diagonal scaling of A that is doubly stochastic. A number of algorithms have been proposed to achieve the balancing, the
Knight, Philip, Ruiz, Daniel
core +2 more sources
On similarity of an arbitrary matrix to a block diagonal matrix
Filomat, 2021 Let an n x n -matrix A have m < n (m ? 2) different eigenvalues ?j of the algebraic multiplicity ?j (j = 1,..., m). It is proved that there are ?j x ?j-matrices Aj, each of which has a unique eigenvalue ?j, such that A is similar to the block-diagonal matrix ?D = diag (A1,A2,..., Am). I.e. there is an invertible matrix T, such that T-1AT
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
M-MATRIX-WP6.M1 - "DASHBOARDS OPERATIONAL WITHIN THE PILOT PARTICIPATING AGENCIES"
, 2022 M-MATRIX-WP6.M1 - “Dashboards operational within the pilot participating agencies” Milestone report for M1 of MATRIX ...
MATRIX
core +1 more source
Representations for the Drazin inverses of block matrices
MATEC Web of Conferences, 2016 In this paper, we investigate representations of the Drazin inverse of a 2 × 2 block matrix. The Drazin inverse of a matrix is very important in various applied mathematical fields like machinery and automation, singular differential equations. We give a
Guo Li, Wang Jie, Du Wenming
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Tropical Matrix Groups with Symmetric Idempotents
Discrete Dynamics in Nature and Society, 2018 In this paper we study the semigroup Mn(T) of all n×n tropical matrices under multiplication. We give a description of the tropical matrix groups containing a diagonal block idempotent matrix in which the main diagonal blocks are real matrices and other ...
Lin Yang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source