Results 121 to 130 of about 2,559,254 (252)

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Rapid Translation of the Early Coding Region Promotes Premature Transcription Termination, Reducing Protein Expression in Escherichia coli

Molecular Microbiology, EarlyView.
A run of consecutive fast‐translated codons (right) within the first 30 codons of lacZ (top) causes loss of the downstream transcript at positions coinciding with previously mapped intragenic Rho‐dependent termination sites (middle), and a corresponding loss of β‐galactosidase activity (bottom).
Steen Pedersen, Alberte Honoré Jepsen, Bertil Gummesson, Namiko Mitarai, Kim Sneppen, Sine Lo Svenningsen   +5 more
wiley   +1 more source

Turbo Detection of Symbol-Based Non-Binary LDPC-Coded Space-time Signals using Sphere Packing Modulation

, 2005
A recently proposed space-time signal construction method that combines orthogonal design with sphere packing, referred to here as (STBC-SP), has shown useful performance improvements over Alamouti’s conventional orthogonal design.
Alamri, O.R., Jiang, M., Hanzo, L., Guo, F.   +3 more
core   +1 more source

TurboID‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

New Phytologist, EarlyView.
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1‐interacting proteins upon different metal regimes. Among validated candidates, the endosome‐localized NHX5 Na+ (K+)/H+ antiporter and the plasma membrane ...
Liza Pellegrin, Steven Fanara, Bertrand Fabre, Carole Pichereaux, Nathalie Leonhardt, Valérie Cotelle, Grégory Vert, Julie Neveu   +7 more
wiley   +1 more source

Cell wall integrity and elicitor peptide signaling modulate jasmonic acid‐mediated camalexin production in Arabidopsis

New Phytologist, EarlyView.
Model of the cell wall damage (CWD)‐responsive signaling network leading to camalexin biosynthesis. Summary Plant cell walls constitute dynamic barriers that are essential for defense against pathogens. Beyond a structural role in blocking pathogen infection, innate mechanisms monitor cell wall integrity (CWI) in Arabidopsis thaliana and trigger local ...
Richard Noi Morton, Lian Fleischberger, Joy Debnath, David Biermann, Susanne Mühlbauer, Ahalya Rajendran, Hans‐Henning Kunz, Julien Gronnier, Nora Gigli Bisceglia, Timo Engelsdorf   +9 more
wiley   +1 more source

Turbo Equalization of Convolutional Coded and Concatenated Space Time Trellis Coded Systems using Radial Basis Function Aided Equalizers

, 2001
In this contribution a reduced-complexity radial basis function (RBF) aided neural-network based turbo equalization (TEQ) scheme is proposed for employment in a serially concatenated convolutional coded and systematic space time trellis coded (CC-SSTTC ...
Yeap, B.L., Yee, M.S., Hanzo, L.
core   +1 more source

Ventricular Synchrony in Targeted Right Ventricular Septal Pacing: A Prospective Paired Comparison to Apical Placement

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background/Objectives Right ventricular (RV) apical pacing, the standard pacing approach, often induces ventricular dyssynchrony, potentially impairing cardiac function. This study aims to investigate whether targeted RV septal pacing, guided by functional electrophysiological feedback during implantation, reduces ventricular dyssynchrony ...
Bianca Iulia Catrina, Mihai Octavian Negrea, Ciprian Tănăsescu, Florina Batar, Florin‐Leontin Lazar, Ioan Manitiu   +5 more
wiley   +1 more source

A Three Amino Acid Sequence Gates Protein Stability Control of bHLH104 and Iron Uptake in Arabidopsis thaliana

Plant, Cell &Environment, EarlyView.
ABSTRACT Iron (Fe) homeostasis is regulated to prevent iron imbalance, with the help of redundant basic helix‐loop‐helix (bHLH) IVc transcription factors that can be controlled by Fe‐binding E3 ligases such as BRUTUS (BTS) in Arabidopsis thaliana.
Dibin Baby, Sarah Weldi, Marie Knopf, Vinitha Venkadasamy, Jessica Lee Erickson, Petra Bauer   +5 more
wiley   +1 more source

The influence of haemoglobin–O2 affinity on aerobic capacity in hypoxia in high‐altitude deer mice (Peromyscus maniculatus)

The Journal of Physiology, EarlyView.
Abstract figure legend The influence of haemoglobin–O2 affinity on aerobic capacity in hypoxia has been contentious. Many high‐altitude natives have greater haemoglobin–O2 affinity (lower P50, the O2 pressure at 50% haemoglobin saturation) than their low‐altitude counterparts, but the advantages of this change for aerobic metabolism have often remained
Kayla M. Garvey, Graham R. Scott
wiley   +1 more source