Results 141 to 150 of about 4,791 (236)

Gene‐specific double‐stranded RNAs induce mortality in the South African mealybug Delottococcus aberiae

open access: yesPest Management Science, Volume 82, Issue 6, Page 5184-5194, June 2026.
Gene‐specific double‐stranded RNAs effectively silence essential genes in the invasive citrus pest Delottococcus aberiae, leading to significant mortality through both microinjection and oral delivery. These results provide proof of concept for RNA interference‐based biopesticides as selective and sustainable tools for citrus integrated pest management.
Carolina Gallego‐Giraldo   +6 more
wiley   +1 more source

Large Language Models for Explainable Medical Text Summarization: A Systematic Literature Review

open access: yesWIREs Data Mining and Knowledge Discovery, Volume 16, Issue 2, June 2026.
The graphical abstract highlights the three key aspects addressed in this review: the technical background of medical text summarization methods relevant to clinical decision support; the LLM background in providing context for its diagnosis and clinical significance; and clinical decision support with summarization and explainability in patient care ...
Aleka Melese Ayalew   +3 more
wiley   +1 more source

Adapting Deep Learning Phase Detectors for Seismic Array Processing

open access: yesJournal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 3, June 2026.
Abstract Deep learning (DL) has considerably advanced single‐station seismic phase detection, but its integration into seismic array processing remains largely unexplored. We evaluate three strategies for adapting the previously developed TPhaseNet detector for regional phase detection to array data: (a) ensemble detection through stacking of single ...
A. Köhler   +3 more
wiley   +1 more source

Leveraging large language models for data analysis automation. [PDF]

open access: yesPLoS One
Jansen JA   +3 more
europepmc   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

open access: yesThe FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar   +6 more
wiley   +1 more source

Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3528-3544, June 2026.
Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek   +12 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

open access: yesThe FEBS Journal, Volume 293, Issue 12, Page 3565-3587, June 2026.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna   +17 more
wiley   +1 more source

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