Results 151 to 160 of about 1,026,952 (386)

Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle [PDF]

, 1969
Théophile Godfraind, A Kaba
openalex   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Blockade of biogenic amine synthesis: its effect on the responses to leptazol and dexamphetamine in rats [PDF]

, 1969
P.S. Spencer, Traci Turner
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The relevance of β‐receptor blockade to ouabain‐induced cardiac arrhythmias [PDF]

, 1969
A N Dohadwalla, A. STONE FREEDBERG, E. M. Vaughan Williams   +2 more
openalex   +1 more source

Public Service Provision, User Fees, and Political Turmoil [PDF]

Following an electoral dispute, the central highlands of the island of Madagascar were subjected to an economic blockade during the Þrst half of 2002. After the blockade ended in June 2002, user fees for health services and school fees were progressively
Bart Minten, Marcel Fafchamps
core  

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Science, 2017
D. Le, D. Le, J. Durham, J. Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Bjarne R. Bartlett, Laveet K. Aulakh, Laveet K. Aulakh, Steve Lu, Steve Lu, H. Kemberling, C. Wilt, Brandon S. Luber, F. Wong, F. Wong, N. Azad, A. Rucki, D. Laheru, R. Donehower, A. Zaheer, G. Fisher, T. Crocenzi, James J. Lee, T. Greten, A. Duffy, K. Ciombor, A. Eyring, B. Lam, A. Joe, S. Kang, M. Holdhoff, Ludmila V. Danilova, L. Cope, C. Meyer, Shibin Zhou, Shibin Zhou, R. Goldberg, D. Armstrong, K. Bever, A. Fader, J. Taube, F. Housseau, D. Spetzler, N. Xiao, D. Pardoll, N. Papadopoulos, N. Papadopoulos, K. Kinzler, K. Kinzler, J. Eshleman, B. Vogelstein, B. Vogelstein, R. Anders, R. Anders, L. Diaz, L. A. Diaz   +57 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Failure of Methyl Palmitate Induced Reticuloendothelial Blockade to Affect Plasma Levels of Factor VIII [PDF]

, 1966
Evelyn Gaynor, Theodore H. Spaet
openalex   +1 more source

Cancer immunotherapy using checkpoint blockade

Science, 2018
A. Ribas, J. Wolchok
semanticscholar   +1 more source