Results 31 to 40 of about 498,550 (314)

Cancer Cell-Intrinsic PD-1 and Implications in Combinatorial Immunotherapy

Frontiers in Immunology, 2018
Programmed death 1 (PD-1) and its two natural ligands PD-L1 and PD-L2 are responsible for delivering inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology.
Han Yao, Huanbin Wang, Chushu Li, Jing-Yuan Fang, Jie Xu   +4 more
doaj   +1 more source

Extracellular blockade of K(+) channels by TEA : results from molecular dynamics simulations of the KcsA channel [PDF]

, 2001
TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to ...
Simon Bernèche, Benoît Roux, Crouzy, S., Roux, B., Serge Crouzy, Bernèche, S.   +5 more
core   +1 more source

Cooperative Optical Non-linearity in a blockaded Rydberg Ensemble [PDF]

, 2011
This thesis describes the observation of a novel optical non-linearity mediated by the dipole-dipole interactions in a cold gas of Rydberg atoms. Electromagnetically induced transparency (EIT) is used to map the strong dipolar interactions onto an ...
Pritchard, Jonathan David, PRITCHARD, JONATHAN,DAVID, Pritchard, Jonathan D.   +2 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Primary perioperative haemodynamic effects of ß-receptor blockade in patients with catecholamine-secreting tumours

BJA Open, 2023
Introduction: Guidelines for the treatment of catecholamine-producing tumours strictly recommend starting ß-receptor blocking medication only after α-receptor blockade has been established.
Harald Groeben, Bente J. Nottebaum, Aarne Feldheiser, Steffen Buch, Piero F. Alesina, Martin K. Walz   +5 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

Frontiers in Behavioral Neuroscience, 2019
Background: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of Cannabis species, and may modulate fear learning in mammals.
Anthony Murkar, Pam Kent, Christian Cayer, Christian Cayer, Jon James, Tony Durst, Zul Merali, Zul Merali, Zul Merali   +8 more
doaj   +1 more source

Don Cossacks and the Battle of Rassevat on September 4, 1809

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2020
Introduction. The Russian-Turkish war of 1806–1812 was the longest military conflict between Russia and Turkey. In the hope to force the Turks to peace, Russian troops crossed the Danube several times and fought for key fortresses on its banks.
Andrey V. Venkov
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

MCT4 blockade increases the efficacy of immune checkpoint blockade

Journal for ImmunoTherapy of Cancer, 2023
Background & Aims Intratumoral lactate accumulation and acidosis impair T-cell function and antitumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, turned out to be prognostic for the survival of patients with rectal cancer, indicating that ...
Babl, Nathalie, Decking, Sonja-Maria, Voll, Florian, Althammer, Michael, Sala-Hojman, Ada, Ferretti, Roberta, Korf, Clarissa, Schmidl, Christian, Schmidleithner, Lisa, Nerb, Benedikt, Matos, Carina, Koehl, Gudrun E., Siska, Peter J., Bruss, Christina, Kellermeier, Fabian, Dettmer, Katja, Oefner, Peter J., Wichland, Marvin, Ugele, Ines, Bohr, Christopher, Herr, Wolfgang, Ramaswamy, Shivapriya, Heinrich, Timo, Herhaus, Christian, Kreutz, Marina, Renner, Kathrin   +25 more
openaire   +4 more sources