Results 51 to 60 of about 424,556 (264)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Veterinary ResearchProgrammed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), function as pivotal immune checkpoints. Numerous studies have demonstrated the association between the malignant progression of various swine diseases and aberrant expression of
Yuwen Dong +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
CRIMEA AND THE POLITICS OF LEGITIMACY IN INTERNATIONAL RELATIONS
Vestnik MGIMO-Universiteta, 2018 Despite the fact that four years have passed since the accession of Crimean peninsula, an active polemic continues in the academic community. Obviously, it somehow sets a certain political discourse not only of the present, but also of the future ...
A. A. Vlasov, A. V. Brega
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Blockade Imposed Against Qatar: An Analytical Study of WTO Principles
International Review of Law, 2019 This analytical study sheds light on the consequences of the blockade imposed against Qatar and the violation of the blockading countries – the Kingdom of Saudi Arabia (KSA), the United Arab Emirates (UAE), Bahrain, and Egypt – of trade and economic ...
آمنة سيف النعيمي +5 more
doaj +2 more sources
Historia Crítica, 2014 This article presents an analysis of the commerce that took place at the mouth of the Salado River, which was born from the war with the Brazilian Empire (1825-1828) in an alternate port to the one in the provincial capital of Buenos Aires.
Antonio Galarza
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
BMC Anesthesiology, 2019 Background Complete avoidance of residual neuromuscular blockade (RNMB) during the postoperative period has not yet been achieved in current anesthesia practice.
Gonzalo Domenech +5 more
doaj +1 more source