Results 61 to 70 of about 789,882 (293)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Coulomb blockade in superconducting quantum point contacts

, 1998
Amplitude of the Coulomb blockade oscillations is calculated for a single-mode Josephson junction with arbitrary electron transparency $D$. It is shown that the Coulomb blockade is suppressed in ballistic junctions with $D\to 1$.
A. Furusaki, C. W. J. Beenakker, D. V. Averin, D. V. Averin, D. V. Averin, D. V. Averin, D. V. Averin, D. V. Averin, E. Akkermans, E. Scheer, G. Schön, H. Takayanagi, I. L. Aleiner, I. S. Gradsteyn, J. Ambjørn, J. C. Cuevas, J. S. Langer, K. Matveev, L. S. Kuzmin, M. A. Kastner, P. Lafarge, P. W. Anderson   +21 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Identification of PD-1–PD-L1 blockade epitopes in vitro utilizing porcine immunoglobulin and heterologous Fc-fused protein

Veterinary Research
Programmed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), function as pivotal immune checkpoints. Numerous studies have demonstrated the association between the malignant progression of various swine diseases and aberrant expression of
Yuwen Dong, Xin Li, Zuxin Gong, Chenchen Liu, Jiaqi Dai, Shuhuai Shen, Zhen Yang, Gongguan Liu   +7 more
doaj   +1 more source

Intrauterine Beta Blockade [PDF]

Pediatric Cardiology, 2015
I read with interest your recent article [2] relating to the intrauterine use of maternal propranolol during the third trimester for the treatment of a fetus with familial hypertrophic cardiomyopathy (HCM). The intrauterine use of beta blockers in this condition has not been attempted before, and the authors are right in registering their concerns as ...
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Immune checkpoint modulation: Tenets and implications in glioblastoma

Glioma, 2019
Glioblastoma (GBM) is the most common primary central nervous system tumor, and despite advances made in traditional chemotherapy and radiation, it continues to carry a poor prognosis.
John P Lynes, Victoria E Sanchez, Anthony K Nwankwo, Gifty A Dominah, Edjah K Nduom   +4 more
doaj   +1 more source

Comparison of epidural levobupivacaine and bupivacaine in lower abdominal and lower limb surgeries

Bali Journal of Anesthesiology, 2020
Background: Bupivacaine, the most commonly used drug for a central neuraxial blockade, also carries undesirable effects like a prolonged postoperative motor blockade.
Jay Prakash, J Prashanth Prabhu, Ramesh Kumar Kharwar, Shio Priye, Dipali Singh, Khushboo Saran   +5 more
doaj   +1 more source

Tunable phonon blockade in weakly nonlinear coupled mechanical resonators via Coulomb interaction

, 2018
Realizing quantum mechanical behavior in micro- and nanomechanical resonators has attracted continuous research effort. One of the ways for observing quantum nature of mechanical objects is via the mechanism of phonon blockade.
Sarma, Amarendra K., Sarma, Bijita
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source