Results 81 to 90 of about 560,572 (303)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2023 Neuromuscular blockade medications are frequently administered during general anesthesia. Residual neuromuscular blockade is assessed with qualitative or quantitative devices to determine the amount of blockade remaining at the end of surgery.
NC DOCKS at East Carolina University +1 more
core
BMC Anesthesiology, 2019 Background Complete avoidance of residual neuromuscular blockade (RNMB) during the postoperative period has not yet been achieved in current anesthesia practice.
Gonzalo Domenech +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Optimized neuromuscular blockade reversal management.
, 2023 Optimized neuromuscular blockade reversal management.
Carlos Ferrando (3494669) +7 more
core +1 more source
MONITORING OF VARIOUS TYPES OF NEUROMUSCULAR BLOCKADE
Вестник анестезиологии и реаниматологии, 2018 Goal of the review: to build up the current understanding of electrophysiological specific features of various neuromuscular blockades. Having analyzed the results of multiple studies devoted to investigation of the impact of various medications ...
N. V. Chubchenko, K. M. Lebedinskiy
doaj +1 more source
PLoS ONE, 2020 BACKGROUND:Deep neuromuscular blockade may facilitate the use of reduced insufflation pressure without compromising the surgical field of vision. The current evidence, which suggests improved surgical conditions compared with other levels of block during
Amit D Raval +8 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The innate power of PD-1 blockade
, 2021 IL-33 and PD-1 blockade induce melanoma clearance via ILC2 recruitment and expansion.
Dhir, Aditi +3 more
core +1 more source