Results 81 to 90 of about 498,550 (314)

Rescue of long-term memory after reconsolidation blockade [PDF]

, 2015
Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdown of
Hall, Jeremy, Barnes, Philip, Thomas, Kerrie L., Trent, Simon   +3 more
core   +1 more source

Usefulness of intra-operative neuromuscular blockade monitoring and reversal agents for postoperative residual neuromuscular blockade: a retrospective observational study

BMC Anesthesiology, 2019
Background Complete avoidance of residual neuromuscular blockade (RNMB) during the postoperative period has not yet been achieved in current anesthesia practice.
Gonzalo Domenech, Matías A. Kampel, María E. García Guzzo, Delfina Sánchez Novas, Sergio A. Terrasa, Gustavo Garcia Fornari   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

MONITORING OF VARIOUS TYPES OF NEUROMUSCULAR BLOCKADE

Вестник анестезиологии и реаниматологии, 2018
Goal of the review: to build up the current understanding of electrophysiological specific features of various neuromuscular blockades. Having analyzed the results of multiple studies devoted to investigation of the impact of various medications ...
N. V. Chubchenko, K. M. Lebedinskiy
doaj   +1 more source

Does deep neuromuscular blockade during laparoscopy procedures change patient, surgical, and healthcare resource outcomes? A systematic review and meta-analysis of randomized controlled trials.

PLoS ONE, 2020
BACKGROUND:Deep neuromuscular blockade may facilitate the use of reduced insufflation pressure without compromising the surgical field of vision. The current evidence, which suggests improved surgical conditions compared with other levels of block during
Amit D Raval, Sohan Deshpande, Silvia Rabar, Maria Koufopoulou, Binod Neupane, Ike Iheanacho, Lori D Bash, Jay Horrow, Thomas Fuchs-Buder   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A novel assay reveals the blockade of esterases by piperonyl butoxide

, 2008
BACKGROUND: Conventional in vitro assays sometimes fail to reveal esterase inhibition by piperonyl butoxide (PBO), although synergism studies suggest loss of esterase-mediated sequestration of insecticide does take place.
Field, L. M., Georgina Bingham, Moores, G. D., Anna C Khot, Bingham, G., Linda M Field, Graham D Moores, Khot, A. C.   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Checkpoint Blockade in Cancer Immunotherapy: Squaring the Circle

, 2015
Manipulating the complex interaction between the immune system and tumour cells has been the focus of cancer research for many years, but it is only in the past decade that significant progress has been made in the field of cancer immunotherapy resulting
Maria A.V. Marzolini, Karl S. Peggs, Sergio A. Quezada   +2 more
core  

I’m blocking because... – Students’ motivations for participating in the student protest in serbia in 2024/2025.

Političke Perspektive
The current student (and civil) protest in Serbia started at the end of November 2024, as a reaction to the fall of the canopy of the Railway station in Novi Sad, during which sixteen people lost their lives.
Jovana Čikić, Ana Bilinović Rajačić
doaj   +1 more source