Results 101 to 110 of about 498,550 (314)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2020 Aims: The effects of sympatho-vagal interaction on heart rate (HR) changes are characterized by vagal dominance resulting in accentuated antagonism. Complex autonomic modulation of ventricular electrophysiology may exert prognostic arrhythmic impact.
SH Chin (8600934) +3 more
core
Beyond Ceasefire: Ending the blockade of Gaza [PDF]
, 2012 The ceasefire agreed between the Government of Israel and Hamas on 21 November 2012, following the recent military escalation in Gaza and southern Israel, provides an unprecedented opportunity to end the cycle of violence that has affected too many ...
Hartberg, Martin
core
Frontiers in Physiology, 2019 ObjectiveOur previous study in heterozygous Ren-2 transgenic rats (TGR) demonstrated that long-term treatment with endothelin receptor A (ETA) blocker atrasentan added to the renin-angiotensin system (RAS) blockade had renoprotective effects in a model ...
Ivana Vaněčková +8 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Physical Review Letters, 2018 We propose how to create and manipulate one-way nonclassical light via photon blockade in rotating nonlinear devices. We refer to this effect as nonreciprocal photon blockade (PB). Specifically, we show that in a spinning Kerr resonator, PB happens when the resonator is driven in one direction but not the other. This occurs because of the {Fizeau drag,}
Huang, Ran +4 more
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Israel Tightens Gaza Blockade, Civilians Bear the Brunt
, 2018 In July 2018, the Government of Israel tightened restrictions on goods and materials entering and leaving Gaza, noting that the measures were in response to Hamas sending incendiary kites and balloons into Israel.
Gorevan, Daniel +3 more
core
An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation
Frontiers in ImmunologyIntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS ...
Liqiong Jiang +21 more
doaj +1 more source