Results 91 to 100 of about 2,099,864 (251)
Efficient estimation of blocking probabilities in non-stationary loss networks [PDF]
, 2002 This paper considers estimation of blocking probabilities in a nonstationary loss network. Invoking the so called MOL (Modified Offered Load) approximation, the problem is transformed into one requiring the solution of blocking probabilities in a ...
Boucherie, R.J., Lassila, P.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Generalized coarsened confounding for causal effects: a large-sample framework
Journal of Causal InferenceThere has been widespread use of causal inference methods for the rigorous analysis of observational studies and to identify policy evaluations. In this article, we consider a class of generalized coarsened procedures for confounding.
Ghosh Debashis, Wang Lei
doaj +1 more source
Efficient Record Linkage in the Age of Large Language Models: The Critical Role of Blocking
AlgorithmsRecord linkage is an essential task in data integration in the fields of healthcare, law enforcement, fraud detection, transportation, biology, and supply chain management.
Nidhibahen Shah +6 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Cognitive LinguisticsIn Dutch verb clusters consisting of an auxiliary and a past participle, both orders of participle and auxiliary are fine. This distinguishes auxiliaries from copular verbs combined with an adjectival participle, for which only the [Part + V]-order is ...
Delaby Gauthier +2 more
doaj +1 more source
, 2017 We define and study a new variant of the secretary problem. Whereas in the classic setting multiple secretaries compete for a single position, we study the case where the secretaries arrive one at a time and are assigned, in an on-line fashion, to one of
Babichenko, Yakov +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
P lasmodium falciparum gametocyte burden in a Tanzanian heterogeneous transmission setting
Malaria JournalBackground Malaria transmission depends on the presence of gametocytes in the peripheral blood of infected human hosts. Understanding malaria infectious reservoirs enables transmission-blocking interventions to target the most important hosts for the ...
Charles Mulamba +8 more
doaj +1 more source